Chemical process for making angiotesin II antagonist compounds

Details Chemical process for making angiotesin II antagonist compounds Chemical process for making angiotesin II antagonist compounds

1992-01-17

1994-03-15

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546276, 548250, 548252, 548253, 548254, C07D25706, C07D40108

Patent

active

052947165

ABSTRACT:
The invention provides a novel chemical process for the manufacture of quinoline, pyridine and imidazole derivatives of the formula IV wherein Q, Y.sup.1 and Y.sup.2 have the various meanings defined herein, and their non-toxic salts, which are angiotensin II inhibitors. The process involves the removal of an electron-deficient phenyl group or a pyridyl or pyrimidyl group from a compound of the formula VI as defined herein.

REFERENCES:
G. Bianchetti et al. "Distacco per idrazinolisi del gruppo 2,4-dinitrofenilico.-Nota II. Idrazinolisi di 1-(2,4-dinitro)fenil-v-triazoli e-tetrazoli." Gazz. Chim. Ital. (1968), 94, 340-355. (Summary in English).
K. Kamala, et al., Bull. Chem. Soc. JPN. (1988) 61, No. 10, 3791-3793; "Synthesis of 2-Aryl[1,2,4]triazolo[1,5-a pyrimidines".
P. G. Houghton, et al., J. Chem. Soc. Perkin Trans I (1985), 1471-1479: "Intramolecular Reaction Between Nitro and Carbodi-imide Groups; A New Synthesis of 2-Arylbenzotriazoles".

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