Chemical process for fluorinating a tertiary carbon atom in the

Details Chemical process for fluorinating a tertiary carbon atom in the Chemical process for fluorinating a tertiary carbon atom in the

1977-03-09

1981-08-18

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603973, 26039745, 2603974, C07J 100

Patent

active

042845580

ABSTRACT:
Saturated organic compounds containing a hydrogen atom bound to a tertiary carbon atom may be electrophilically fluorinated by reaction with an electrophilic fluorinating agent such as molecular fluorine or trifluoromethyl hypofluorite under conditions whereby the formation of free fluorine radicals is suppressed, e.g. by the presence of a free radical inhibitor such as oxygen or nitrobenzene, the reactants being substantially homogeneously dispersed in a liquid medium, e.g. a solvent medium such as fluorotrichloromethane or chloroform/fluorotrichloromethane, so that the said hydrogen atom is electrophilically replaced by a fluorine atom. The fluorination is highly selective and, in the case of complex substrates such as saturated steroids which contain a number of tertiary C--H bonds, may be substantially completely confined to replacement of the hydrogen atom at the tertiary carbon atom which has the highest electron density about the C--H bond. The electron density and thus the direction of the fluorination may be controlled by appropriate selection of substituent groupings in the substrate molecule.
Novel 14.alpha.-fluorosteroids are also disclosed, including compounds having valuable androgenic or progestational activity and useful synthetic intermediates.

REFERENCES:
patent: 3687943 (1972-08-01), Barton et al.
patent: 4036864 (1977-07-01), Barton et al.

Affiliated with

Also associated with

Rating

Chemical process for fluorinating a tertiary carbon atom in the does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemical process for fluorinating a tertiary carbon atom in the , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemical process for fluorinating a tertiary carbon atom in the will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-37040