Chemical process and intermediates used therein

Details Chemical process and intermediates used therein Chemical process and intermediates used therein

1993-01-25

1994-08-02

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544328, 544331, C07D47104

Patent

active

053347188

ABSTRACT:
The invention provides a novel chemical process for the manufacture of certain imidazo[4,5-b]pyridine derivatives of the formula I wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the various meanings defined herein, and their non-toxic salts, which are angiotensin II inhibitors. The process involves the removal of an electron-deficient phenyl group or a pyridyl or pyrimidyl group from a compound of the formula II as defined herein. Certain of the intermediates are novel and are provided as a further feature of the invention.

REFERENCES:
G. Bianchetti, et al., "Distacco per Idrazinolisi del Gruppo 2,4-Dinitrofenilico.-Nota II. Idrazinolisi di 1-(2,4-dinitro)-fenil-v-triazoli e-tetrazoli" Gazz. Chim. Ital., 1964, 94, 340-350.

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