Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2007-10-31
2010-12-14
Wilson, James O (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C548S503000
Reexamination Certificate
active
07851623
ABSTRACT:
The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-[(4-fluoro-2-methy-1-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline starting from a compound of Formula IX:wherein R4is a protecting group; or an intermediate there between, using process steps, reagents and conditions as described.
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Arnott Euan Alexander
Crosby John
Evans Matthew Charles
Ford James Gair
Jones Martin Francis
AstraZeneca AB
Morgan & Lewis & Bockius, LLP
Willis Douglas M
Wilson James O
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