Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From boron reactant having at least one boron to hydrogen or...
Patent
1995-02-09
1996-04-02
Marquis, Melvyn I.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
From boron reactant having at least one boron to hydrogen or...
525356, 5253592, 5253594, 5253596, 570185, 570189, 570201, 570253, C08G 7908, C07C 2200, C08C 1912
Patent
active
055041736
DESCRIPTION:
BRIEF SUMMARY
This invention relates to a bromination process and more particularly to a process for the bromination of methyl 2-(2-methylphenyl)-3-methoxypropenoate.
A process for brominating (E)-methyl 2-(2-methylphenyl)-3-methoxypropenoate with bromine in chloroform in the presence of azodiisobutyronitrile and light is described in EP-A-0278595. A process for brominating (Z)-methyl 2-(2-methylphenyl)-3-methoxypropenoate to form (E)-methyl 2-(2-bromomethylphenyl)-3-methoxypropenoate using N-bromosuccinimide is described in EP-A-0299694. The side chain bromination of aromatic molecules with a bromine complex of poly(styrene-co-4-vinylpyridine) is described in J. Org. Chem. 1986, 51, 929-931.
According to the present invention there is provided an improved process for preparing a compound of formula (I) which comprises contacting with bromine the (E)- or (Z)-isomer of a compound of formula (II) or a mixture of both isomers, in an inert organic solvent, in the presence of a polymeric base (as hereinafter defined) and light.
By "inert organic solvent" is meant an organic solvent which does not react chemically to any significant extent with bromine under the conditions of the process. Suitable solvents include halogenated, for example chlorinated, aliphatic and aromatic organic solvents having a boiling point not less than 20.degree. C., for instance carbon tetrachloride and chlorobenzene.
By the term "polymeric base" is meant an organic polymer comprising repeat units containing a basic group which will form a salt with an inorganic acid, in this case hydrogen bromide, without generating water. For example, the basic group may be an amino group, such as a tertiary amino group. Typically the polymeric base will comprise repeat units containing a tertiary nitrogen atom which is a member of a heterocyclic ring. The heterocyclic ring may be aromatic, for example a pyridine ring, or non-aromatic, for example, a pyrrolidine ring. Suitable polymeric bases include cross-linked poly(vinylpyridine) polymers, cross-linked copolymers of styrene and vinylpyridine, for instance 4-vinylpyridine, and poly(N-vinylpyrrolidone) polymers. Commercially available examples include poly(4-vinylpyridine) 2% cross-linked with divinylbenzene, poly(2-vinylpyridine-co-styrene) having a styrene content of 30%; poly(4-vinylpyridine-co-styrene) having a styrene content of 10%; polyvinylpyrrolidone, cross-linked (PVPDC) mp>300.degree. C.; and polyvinylpyrrolidone (povidone, PVP) of varying average molecular weights of 10,000, 24,000, 40,000 and 360,000. Ideally, the polymeric base should be insoluble in the solvent under the conditions of the process, thereby facilitating recovery after use. The recovered polymeric material may then be regenerated by treatment with, for example, an aqueous base and dried ready for re-use.
The process of the invention is suitably carried out at a temperature of from 20.degree. C. to 80.degree. C., typically from 25.degree. C. to 75.degree. C., but may be limited by the boiling point of the solvent used. Examples of suitable operating temperatures are 55.degree. C. to 70.degree. C., for instance 60.degree. C. to 65.degree. C. or 65.degree. C. to 70.degree. C., and 20.degree. C. to 25.degree. C.
The process of the invention is conveniently carried out by the slow, for example dropwise, addition of bromine to a stirred mixture of the compound (II) and the pre-dried polymeric base in the inert organic solvent whilst irradiating the mixture with visible light. The visible light may be supplied by a tungsten-halogen lamp.
The starting materials, which may be the (E)- or (Z)-isomers of compound (II) or a mixture of both, and their methods of preparation are already described in the chemical literature. For example, the preparation of (E)-methyl 2-(2-methylphenyl)-3-methoxypropenoate is described in EP-A-0203606 and the preparation of the (Z)-isomer is described in EP-A-0299694.
The invention provides a high-yielding process for an intermediate chemical useful in the manufacture of fungicides of the type described in, for exa
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"Journal of Organic Chemistry" pp. 929-931, vol. 51 Mar. 21, 1986, Sket et al.
Foster Nicholas R.
Williams Alfred G.
Gulakowski Randy
Marquis Melvyn I.
Thomson Marian T.
Zeneca Limited
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