Chemical process

Details Chemical process Chemical process

1981-03-30

1982-12-07

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 59, 549 60, 549 76, 549305, 549310, 548127, 548215, 548253, 548336, 546248, 546284, 544333, 544405, C07D33324, C07D23900, C07D21120, C07D40300

Patent

active

043628800

ABSTRACT:
An improved process for the preparation of 3-substituted thiophenes. The thiophenes are useful for the preparation of penicillins and cephalosporins.
The process is for the preparation of a thiophene of formula (I): ##STR1## where R.sup.1 represents a carboxylic acid group, or an ester or amide thereof or a nitrile group; R.sup.2 represents a group suitable for use as an .alpha.-substituent in the side-chain of a penicillin or cephalosporin; which comprises treating under basic conditions a compound of formula (II): ##STR2## wherein X represents halogen or optionally functionalized hydroxyl, Y represents halogen, hydroxyl, or alkoxy; with a source of nucleophilic sulphur ionically bound to a polymeric support.

REFERENCES:
patent: 4252976 (1981-02-01), Guest et al.

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