Chemical process

Details Chemical process Chemical process

1990-03-05

1991-08-27

Willis, Prince E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C12166

Patent

active

050434675

ABSTRACT:
A process for the production of a substituted amide of the formula: ##STR1## where R.sup.1 is an optionally substituted aryl group, X.sup.1 is --O-- or --S-- and R.sup.2 is an optionally substituted alkyl, alkenyl, or alkynyl group or X.sup.1 R.sup.2 is an N-linked 5-membered nitrogen heterocycle comprising the halogenation, preferably bromination, in an inert solvent of a N-cyanomethyl-amide of the formula R.sup.1 --CONH.CH.sub.2 CN, followed by addition to the halogenated mixture, or to the mixture as halogenation is taking place, of a heterocyclic tertiary amine in a proportion of from about 1.0 to about 2.5 moles, and preferably from 1.3 to 2.1 moles, for each mole of halogen reacted, and finally treatment of the resulting quaternary salt with an alcohol, thiol or amine of the formula R.sup.2 X.sup.1 H.

REFERENCES:
patent: 4447446 (1984-05-01), Kay et al.
patent: 4575557 (1986-03-01), Jones et al.
patent: 4579581 (1986-04-01), Kay et al.
patent: 4663481 (1987-05-01), Jones et al.
patent: 4786747 (1988-11-01), Jones et al.

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