Chemical process

Details Chemical process Chemical process

1998-01-27

1999-08-10

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562433, C07C22960

Patent

active

059361190

ABSTRACT:
The invention provides a process for the preparation of 3-(N,N-dimethylamino)benzoic acid which comprises subjecting an aqueous solution of an alkali metal salt or ammonium salt of 3-aminobenzoic acid to reductive methylation in the presence of a supported transition metal catalyst, by the controlled and continuous addition of a solution of formaldehyde over a period of 0.5 to 20 hours with a hydrogen pressure between 1 bar and 40 bar and with the temperature of the reaction mass gradually raised during the reduction, the reaction being carried out within the temperature range of 20.degree. C. to 120.degree. C., and wherein a buffering agent is added such that the pH of the reaction mass after reductive methylation is from 6.5 to 9.5.

REFERENCES:
patent: 4233458 (1980-11-01), Bright et al.
Database CAPLUS on STN, Acc. No. 1991:81171, Wen et al., `Preparation of meta-(dimethylamino)benzoic acid.` Huaxue Shiji (1990), 12(4), p. 243, abstract.
Derwent Abst. 77-53156y.
Chem. Abst. 120:133965m.

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