Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1991-03-01
1992-01-07
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514312, 546153, 546155, 546156, 564218, A61K 31165, C07C23354
Patent
active
050792644
ABSTRACT:
A process to prepare compounds of formula I ##STR1## in which n=0, 1 or 2 comprising the cyclization of compounds of formula II ##STR2## in which n=0, 1 or 2. The cyclization may be effected in the presence of an organic or inorganic base or thermally at a temperature in the range 40.degree.-160.degree. C.
Compounds of formula II and certain analogues thereof are disclosed as cardiovascular agents.
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Barron Kenneth
Harrison Albert E.
MacLean Lachlan
Nichol Kenneth J.
Roberts David L.
Hollrah Glennon H.
The Boots Co. PLC
Treanor Susan P.
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