Chemical process

Details Chemical process Chemical process

1992-11-20

1994-07-05

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544206, C07D48704

Patent

active

053268695

ABSTRACT:
A process for the preparation of a 5,7-diaryloxy-2-(2-heteroaryl)-triazolo[1,5-a][1,3,5]triazine, which comprises reacting a N-2-(4,6-diaryloxy)-[1,3,5]triazinyl-N'-(2-heteroarylcarbonyl)hydrazine with a polyphosphoric acid silyl ester. The invention also provides a multistep process for preparing certain triazolotriazines having activity asadenosine antagonists.

REFERENCES:
Imamoto, et al., Tet. Lett., 22, 1803, 1981, "Trimethyl Polyphosphate (PPSE). A Useful Reagent For the Beckmann Rearrangement".
K. Yamamoto, et al., Chem. Lett., 1225, 1982, "Composition of Polyphosphoric Acid Trimethylsilyl Ester . . . ".
T. Imamoto, et al., Tet. Lett., 23, 1467, 1982, "The Reaction of Aryl Methyl Ketones with Aromatic Aldehydes in Trimethylsilyl Polyphosphate (PPSE) . . . ".
M. Yokoyama, et al., Synthesis, 591, 1982, "Organic Reactions Using Trimethylsilyl Polyphosphate (PPSE): A Convenient Synthesis of Nitriles from Carboxamides".
T. Inamoto, et al., Synthesis, 460, 1983, "A Convenient Method for the Preparation of Alkyl Iodides From Alcohols".
J. M. Aizpuru, et al., Bull. Soc. Chim. Fr., II-142, 1983, "Reagents and Synthetic Methods . . . ".
M. Kakimoto, et al., Chem. Lett. 821, 1984, "A Novel Direct Synthesis of Amidines from Carboxylic Acids And Amines Using Polyphosphoric Acid . . . ".
T. Imamoto, et al., J. Org. Chem., 49, 1105, 1984, "Preparation and Synthetic Use of Trimethylsilyl Polyphosphate. A New Stereoselective Aldol-Type . . . ".
M. Kakimoto, et al., Chem. Lett. 1831, 1984, "Pummerrer Rearrangement Promoted by Polyphosphoric Acid Trimethylsilyl Ester (PPSE)".
Y. Okamoto, Bull. Chem. Soc., Jpn., 58, 3393, 1985, "Synthesis of Alkyl Dihydrogenphosphate by the Reaction of Alcohols and Silyl Polyphosphate".
S. Ogata, et al., Bull. Chem. Soc. Jpn., 59, 2171, 1986, "Synthesis of Amides and Amidines by Reaction of Carboxylic Acids and Amines . . . ".
M. Kakimoto et al., Synthesis, 164, 1987, "Synthesis of Dithioacetals from Carbonyl Compounds and Thiols In the Presence of Polyphosphoric Acid . . . ".
M. Kakimoto, et al., Bull. Chem. Jpn., 61, 2643, 1988, "Pinacol-Pinacolone Rearrangement Promoted by Polyphosphoric Acid Trimethylsilyl Ester (PPSE)".
E. M. Berman et al., J. Org. Chem., 54, 5642, 1989, "Trimethylsilyl Polyphosphate for Intramolecular Friedel-Crafts Cyclizations".
C. Fluozat et al., Synthesis, 64, 1990, "A New Convenient Synthesis of 2-Aryl-And 2-Heteroaryloxazolo . . . ".
Deshpande, et al., Synthesis, 863, 1974, "Synthesis of s-Triazolo . . . ".
Imai et al., Synthesis, 851, 1983, "A Convenient Synthesis of 2H-1,2,4-Benzothiadiazine . . . ".

Affiliated with

Also associated with

Rating

Chemical process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemical process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemical process will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-796921