Chemical probes for left-handed DNA and chiral metal complexes a

Details Chemical probes for left-handed DNA and chiral metal complexes a Chemical probes for left-handed DNA and chiral metal complexes a

1987-07-22

1990-12-25

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424 9, C07D47104, A61K 31555, C12Q 168, C07H 1900

Patent

active

049804731

ABSTRACT:
This invention concerns a coordination complex and salts and optically resolved enantiomers thereof, of the formula (R).sub.3 --M, wherein R comprises 1,10-phenanthroline or a substituted derivative thereof, M comprises a suitable transition metal, e.g. ruthenium(II) or cobalt(III), and R is bonded to M by a coordination bond.
The complexes of this invention are useful in methods for labeling, nicking and cleaving DNA. The lambda enantiomer of complexes of this invention is useful in methods for specifically labeling, detecting, nicking and cleaving Z-DNA.
The complexes may also be used in a method for killing tumor cells and may be combined with a pharmaceutically acceptable carrier to form a pharmaceutical composition for the treatment of tumor cells in a subject. The invention further concerns methods for treating a subject afflicted with tumor cells.

REFERENCES:
Barton et al., I Proc. Natl. Acad Sci. 81, Apr. 1984 pp. 1961-1965.
Barton et al. II, J. Amer. Chem. Soc. 106, 2467 (1984).
Dollimore, J. Chem. Soc. Dalton, 1973, 933-940.

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