Chemical prevention or reversal of cataract by phase separation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514912, A61K 3116

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active

050914219

ABSTRACT:
The present invention relates to methods and pharmaceutical reagents for decreasing the phase separation temperature and inhibiting the formation of high molecular weight aggregates in eye lenses, thereby inhibiting or reversing cataract formation.

REFERENCES:
patent: 2411572 (1946-11-01), Dickey et al.
patent: 3124508 (1964-03-01), Nordmann
patent: 3892824 (1975-07-01), Piper et al.
patent: 3920810 (1975-11-01), Rankin
patent: 4080264 (1978-03-01), Cohen et al.
patent: 4350163 (1982-09-01), Ford, Jr. et al.
patent: 4350677 (1982-09-01), von Schulthess et al.
patent: 4351826 (1982-09-01), Clark et al.
patent: 4424216 (1984-01-01), Cerami et al.
patent: 4451477 (1984-05-01), Silvestrini et al.
patent: 4474817 (1984-10-01), Clark et al.
patent: 4526789 (1985-07-01), Clark et al.
patent: 4537892 (1985-08-01), York et al.
patent: 4611074 (1986-09-01), Shealy et al.
patent: 4656034 (1987-04-01), Sarnoff
patent: 4665089 (1987-05-01), Siezen et al.
patent: 4702576 (1987-10-01), Magnante
patent: 4711542 (1987-12-01), Ichihashi et al.
patent: 4719912 (1988-01-01), Weinberg
patent: 4727174 (1988-02-01), Shealy et al.
Chem. Abst., 104:10655x (1986), Marutani et al.
Biosis, 5806012 (1986), Efimov et al.
Efimov et al., "The Role of Sorbitol Metabolic Pathway in Therapeutic Mechanisms of Pantethine in Diabetic Models", Khim-FarmZH, 20(8):912-4, 1986 (English translation enclosed).
Tsutsumi et al., "Wirkung von Pantothensaurenderivaten auf den durch Hyperlaktosediat hervorgerufenen Katarakt in Ratten", Deutsche Aoptheker-Zeitung, 108(33):1204, 1968 (English translation enclosed).
Zigman and Lerman, "A Cold Precipitable Protein in the Lens", Nature, 203:662-3, 1964.
Dublin et al., "Observation of the Spectrum of Light Scattered by Solutions of Biological Macromolecules", Proc. Natl. Acad. Sci. USA, 57(5):1164-71, 1967.
N. Clark et al., "A Study of Brownian Motion Using Light Scattering", Am. Jour. Phys., 38(5):575-85, 1970.
Benedek, "Theory of Transparency of the Eye", Applied Optics, 10:459-73, 1971.
Jedziniak et al., "Calcium-Induced Aggregation of Bovine Lens Alpha Crystallins", Invest. Ophthal., 2:905-15, 1972.
Jedziniak et al., "On the Presence and Mechanism of Formation of Heavy Molecular Weight Aggregates in Human Normal and Cataractous Lenses", Exp. Eye Res, 15:185-92, 1973.
Tanaka and Benedek, "Observation of Protein Diffusivity in Intact Human and Bovine Lenses with Application to Cataract", Invest. Ophthal., 14(6):449-56, 1975.
Lubin et al., "Dimethyl Adipimidate: A New Antisickling Agent", Proc. Natl. Acad. Sci. USA, 72(1):43-6, 1975.
Waterman et al., "Anti-Sickling Nature of Dimethyl Adipimidate", Biochem. Biophys. Res. Com., 63(3):580-7, 1975.
Jedziniak et al., "The Concentration and Localization of Heavy Molecular Weight Aggregates in Aging Normal and Cataractous Human Lenses", Exp. Eye Res., 20:367-69, 1975.
Jedziniak et al., "On the Calcium Concentration of Cataractous and Normal Human Lenses and Protein Fraction of Cataractous Lenses", Exp. Eye Res., 23:325-32, 1976.
Tanaka and Ishimoto, "In Vivo Observation of Protein Diffusivity in Rabbit Lenses", Invest. Ophthal., 16(2):135-40, 1977.
Lion Dentifrice Co., Ltd., "Stable Eye Drops Containing Pantothenic Acid", Japan Kokai, 78 62,820, Jun. 5, 1978 (cited in Chem. Abstracts 89:1358773, 1978).
Jedziniak et al., "Quantitative Verification of the Existence of High Molecular Weight Protein Aggregates in the Intact Normal Human Lens by Light-Scattering Spectroscopy", Invest. Ophthal. Vis. Sci., 17(1):51-7, 1978.
Benedek et al., "Light Scattering and Reversible Cataracts in the Calf and Human Lenses", Phil. Trans. R. Soc. Lond., A293:329-40, 1979.
Ishimoto et al., "Cytoplasmic Phase Separation in Formation of Galactosemic Cataract in Lenses of Young Rats", Proc. Natl. Acad. Sci. USA, 76(9):4414-36, 1979.
Clark and Benedek, "The Effects of Glycols, Aldehydes and Acrylamide on Phase Separation and the Opacification in the Calf Lens", Invest. Ophthal. Vis. Sci., 19(7):771-6, 1980.
Clark and Benedek, "Phase Diagram for Cell Cytoplasma from the Calf Lens", Biochem. Biophys. Res. Com., 95(1):489-9, 1980.
Siezen et al., "The Quaternary Structure of Bovine .alpha.-Crystallin", Eur. J. Biochem., 107:243-9, 1980.
Clark et al., "Cortical Opacity, Calcium Concentration and Fiber Membrane Structure in the Calf Lens", Exp. Eye Res., 31:399-410, 1980.
Benedek and Clark, "Light Scattering in the Lens: Phase Transition and Opacification", Developments in Biochem., 9, Red Blood Cell and Lens Metabolism (Srivastava ed.), pp. 431-4, 1980.
Clark et al., "Scanning Electron Microscopy of Opaque and Transparent States in Reversible Calf Lens Cataracts", Ophthal. Res., 12:16-33, 1980.
Clark et al., "Laser Light Scattering and Cataract", Proc. of Tech. Conf. on Electro-Optics and Lasers, pp. 365-70, 1981.
Delaye et al., "Coexistence Curves for Phase Separation in the Calf Lens Cytoplasm", Biochem. Biophys. Res. Com., 100:908-14, 1981.
Clark et al., "Phase Separation in X-Irradiated Lenses of Rabbit", Invest. Ophthal. Vis. Sci., 22(2):186-90, 1982.
Delaye et al., "Identification of the Scattering Elements Responsible for Lens Opacification in Cold Cataracts", Biophys. J., 37:647-56, 1982.
Nemes et al., "Chemical Modification of Rhodopsin with Imidoesters: Synthesis of Reagents, Membrane Permeability of Reagents, and Modification Methods", Methods in Enzymol., 81:275-85, 1982.
Clark et al., "Preparation and Characterization of Native Lens Cell Cytoplasm", Curr. Eye Res., 1:695-704, 1982.
Ross et al., "Radiation Cataract Formation Diminished by Vitamin E in Rat Lenses In Vitro", Exp. Eye Res., 36(5):645-53, 1983.
Tanaka et al., "Phase Separation in Rat Lenses Cultured in Low Glucose Media", Invest. Ophthal. Vis. Sci., 24(4):522-5, 1983.
Middaugh et al., "Chemical Crosslinking of Cell Membranes", Molecular and Cellular Biochem., 50:115-41, 1983.
Benedek, "Why the Eye Lens is Transparent", Nature, 302(5907):383-384, 1983.
Davidson et al., "Biological Characteristics of Some Improved Radioprotectors", Radiation Sensitizers, pp. 308-320, 1983.
Kador, "Overview of the Current Attempts Toward the Medical Treatment of Cataract", Ophthalmology, 90(4):352-364, 1983.
Clark et al., "Phase Separation and Lens Cell Age", J. Gerontol., 38:287-292, 1983.
Hammer and Benedek, "The Effect of Naturally Occurring Cellular Constituents on Phase Separation and Opacification in Calf Lens Nuclear Homogenates", Curr. Eye Res., 2(12):809-814, 1983.
Zeimer and Noth, "A New Method of Measuring In Vivo the Lens Transmittance, and Study of Lens Scatter, Fluorescence and Transmittance", Ophthal. Res., 16(5):246-255, 1984.
Nishio et al., "In Vivo Observation of Lens Protein Diffusivity in Normal and X-Irradiated Rabbit Lenses", Exp. Eye Res., 39(1):61-68, 1984.
"Chemical Protection Against Ionizing Radiation", Federal Emergency Management Agency, Final Report, 1984.
Benedek, "The Molecular Basis of Cataract Formation", Human Cataract Formation, CIBA Foundation Symposium, 106, pp. 236-247, 1984.
Creighton et al., "Modeling Cortical Cataractogenesis VII: Effects of Vitamin E Treatment on Galactose-Induced Cataracts", Exp. Eye Res., 40(2):213-222, 1985.
Libondi et al., "In Vitro Effect of Alpha-Tocopherol on Lysophosphatidylcholine-Induced Lens Damage", Exp. Eye. Res., 40(5):661-666, 1985.
Crompton et al., "Aspirin Prevents Carbamylation of Soluble Lens Proteins and Prevents Cyanate-Induced Phase Separation Opacities In Vitro: A Possible Mechanism by Which Aspiring Could Prevent Cataract", Exp. Eye Res., 40(2):297-311, 1985.
Seizen et al., "Permanent Suppression of Phase Separation Cataract in Calf Lenses Using Amine Modification Agents", Biochem. Biophys. Res. Comm., 133(1):239-247, 1985.
Siezen and Benedek, "Controlled Modulation of the Phase Separation and Opacification Temperature of Purified Bovine .gamma.IV-Crystallin", Current Eye Res., 4(10):1077-1085, 1985.
Weale, "Human Lenticular Fluorescence and Transmittivity, and Their Effects on Vision", Exp. Eye Res., 41(4):457-473, 1985.
Clark, "Bedeutung der Phase-Umwandlung fur die Kataraktentwicklung?", Biochemie des Auges, D. Hockwin (ed).,

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