Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1993-08-09
1994-03-01
Fay, Zohreh A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514724, 514912, A61K 31195, A61K 31045
Patent
active
052908135
ABSTRACT:
The present invention relates to methods and pharmaceutical reagents for decreasing the phase separation temperature and inhibiting the formation of high molecular weight aggregates in eye lenses, thereby inhibiting or reversing cataract formation.
REFERENCES:
patent: 2411572 (1946-11-01), Dickey et al.
patent: 3124508 (1964-03-01), Nordmann
patent: 3892824 (1975-07-01), Piper et al.
patent: 3920810 (1975-11-01), Rankin
patent: 4080264 (1978-03-01), Cohen et al.
patent: 4350163 (1982-09-01), Ford, Jr. et al.
patent: 4350677 (1982-09-01), von Schulthess et al.
patent: 4351826 (1982-09-01), Clark et al.
patent: 4424216 (1984-01-01), Cerami et al.
patent: 4451477 (1984-05-01), Silvestrini et al.
patent: 4474817 (1984-10-01), Clark et al.
patent: 4526789 (1985-07-01), Clark et al.
patent: 4537892 (1985-08-01), York et al.
patent: 4611074 (1986-09-01), Shealy et al.
patent: 4656034 (1987-04-01), Sarnoff
patent: 4665089 (1987-05-01), Siezen et al.
patent: 4702576 (1987-10-01), Magnante
patent: 4711542 (1987-12-01), Ichihashi et al.
patent: 4719912 (1988-01-01), Weinberg
patent: 4727174 (1988-02-01), Shealy et al.
Efimov et al., "The Role of Sorbitol Metabolic Pathway in Therapeutic Mechanisms of Pantethine in Diabetic Models," Khim-FarmZH 20(8):912-4, (1986).
Tsutsumi et al., "Wirkung von Pantothensaurenderivaten auf den durch Hyperlaktosediat hervorgerufenen Katarakt in Ratten," Deutsche Aoptheker-Zeitung 108(33)1204, (1968).
Zigman and Lerman, "A Cold Precipitable Protein in the Lens," Nature 203:662-3, (1964).
Dubin et al., "Observation of the Spectrum of Light Scattered by Solutions of Biological Macromolecules,"Proc. Natl. Acad. Sci. USA 57(5):1164-71, (1967).
N. Clark et al., "A Study of Brownian Motion Using Light Scattering," Am. Jour. Phys. 38(5):575-85, (1970).
Benedek, "Theory of Transparency of the Eye," Applied Optics 10:459-73, (1971).
Jedziniak et al., "Calcium-Induced Aggregation of Bovine Lens Alpha Crystallins," Invest. Opthal. 2:905-15, (1972).
Jedziniak et al., "On the Presence and Mechanism of Formulation of Heavy Molecular Weight Aggregates in Human Normal and Cataractous Lenses," Exp. Eye Res. 15:185-92, (1973).
Tanaka and Benedek, "Observation of Protein Diffusivity in Intact Human and Bovine Leses with Application to Cataract," Invest. Ophthal. 14(6):449-56, (1975).
Lubin et al., "Dimethyl Adipimidate: A New Antisickling Agent," Proc. Natl. Acad. Sci. USA 72(1):43-6, (1975).
Waterman et al., "Anti-Sickling Nature of Dimethyl Adipimidate," Biochem. Biophys. Res. Com. 63(3):580-7, (1975).
Jedziniak et al., "The Concentration and Localization of Heavy Molecular Weight Aggregates in Aging Normal and Cataractous Human Lenses," Exp. Eye Res. 20:367-69, (1975).
Jedziniak et al., "On the Calcium Concentration of Cataractous and Normal Human Lenses and Protein Fractions of Cataratous Lenses," Exp. Eye Res. 23:325-32, (1976).
Tanaka and Ishimoto, "In Vivi Observation of Protein Diffusivity in Rabbit Lenses," Invest. Ophthal. 16(2):135-40, (1977).
Lion Dentifrice Co., Ltd., "Stable Eye Drops Containing Pantothenic Acid," Japan Kokai 78 62,820, Jun. 5, (1978) (cited in Chem. Abstracts 89:1358773, 1978).
Jedziniak et al., "Quantitative Verification of the Existence of High Molecular Weight Protein Aggregates in the Intact Normal Human Lens by Light-Scattering Spectroscopy," Invest. Ophthal. Vis. Sci. 17(1):51-7, (1978).
Benedek et al., "Light Scattering and Reversible Cataracts in the Calf and Human Lenses," Phil. Trans. R. Soc. Lond. A293:329-40, (1979).
Ishimoto et al., "Cytplasmic Phase Seperation in Formation of Galactosemic Cataract in Lenses of Young Rats," Proc. Natl. Acad. Sci. USA 76(9):4414-36, (1979).
Clark and Benedek, "The Effects of Glycols, Aldehydes and Acrylamide on Phase Separation and the Opacification in the Calf Lens," Invest. Ophthal. Vis. Sci. 19(7):771-6, (1980).
Clark and Benedek, "Phase Diagram for Cell Cytoplasm From the Calf Lens," Biochem. Biophys. Res. Com. 95(1):482-9, (1980).
Siezen et al., "The Quaternary Structure of Bovine .alpha.-Crystallin," Eur. J. Biochem. 107:243-9, (1980).
Clark et al., "Cortical Opacity, Calcium Concentration and Fiber Membrane Structure in the Calf Lens," Exp. Eye Res. 31:399-410, (1980).
Benedek and Clark, "Light Scattering in the Lens: Phase Transition and Opacification," Developments in Biochem 9, Red Blood Cell and Lens Metabolism (Srivastava ed.), pp. 431-4, (1980).
Clark et al., "Scanning Electron Microscopy of Opaque and Transparent States in Reversible Calf Lens Cataracts," Ophthal Res. 12:16-33, (1980).
Clark et al., "Laser Light Scattering and Cataract, " Proc. of Tech. Conf. on Electro-Optics and Lasers, pp. 365-70, (1981).
Delaye et al., "Coexistence Curves for Phase Separation in the Calf Lens Cytoplasm," Biochem. Biophys. Res. Com. 100:908-14, (1981).
Clark et al., "Phase Separation in X-Irradiated Lenses of Rabbit," Invest. Ophthal. Vis. Sci. 22(2):186-90, (1982).
Delaye et al., "Identification of the Scattering Elements Responsible for Lens Opacifivation in Cold Cataracts," Biophys J. 37:647-56, (1982).
Nemes et al., "Chemical Modification of Rhodopsin With Imidoesters: Synthesis of Reagents, Membrane Permeability of Reagents, and Modification Methods," Methods in Enzymol. 81:275-85, (1982).
Clark et al., "Preparation and Characterization of Native Lens Cell Cytoplasm," Curr. Eye Res. 1:695-704, (1982).
Clark and Carper, "Phase Separation in Lens Cytoplasms in Genetically Linked to Cataract Formation in the Philly Mouse," Proc. Natl. Acad. Sci. USA 84:122-5, (1987).
Ross et al., "Radiation Cataract Formation Diminished by Vitamin E in Rat Lenses In Vitro," Exp. Eye Res. 36(5):645-53, (1983).
Benedek et al., "Quantitative Detection of the Molecular Changes Associated with Early Cataractogenesis in the Living Human Lens Using Quasielastic Light Scattering," Current Eye Res. 6(12):1421-32, (1987).
Tanaka et al., "Phase Separation in Rat Lenses Cultured in Low Glucose Media," Invest. Ophthal Vis. Sci. 24(4):522-5, (1983).
Eccarius and Clark, "Effect of Aspirin and Vitamin E on Phase Separation in Calf Lens Homogenate," Ophthal. Res., 19:65-71, (1987).
Middaugh et al., "Chemical Crosslinking of Cell Membranes," Molecular and Cellular Biochem. 50:115-41, (1983).
Thomson et al., "Binary Liquid Phase Separation and Critical Phenomena in a Protein/Water Solution," Proc. Natl. Acad. Sci. USA 84:7079-83, (1987).
Benedek, "Why the Eye Lens is Transparent," Nature 302(5907):383-384, (1983).
Siezen et al., "Rat Lens .gamma.-Crystallins Characterization of the Six Gene Products and Their Spatial and Temporal Distribution Resulting From Differential Synthesis," J. Mol. Biol. 199:475-90, (1988).
Davidson et al., "Biological Characteristics of Some Improved Radioprotectors," Radiation Sensitizers, pp. 308-320, (1983).
Kador, "Overview of the Current Attempts Toward the Medical Treatment of Cataract," Ophthalmology 90(4):352-64, (1983).
Clark et al., "Phase Separation and Lens Cell Age," J. Gerontol . 38:287-92, (1983).
Hammer and Benedek, "The Effect of Naturally Occuring Cellular Constituents on Phase Separation and Opacification in Calf Lens Nuclear Homogenates," Curr. Eye Res. 2(12):809-14, (1983).
Zeimer and Noth, "A New Method of Measuring In Vivo the Lens Transmittance, and Study of Lens Scatter, Fluorescence and Transmittance," Ophthal. Res. 16(5):246-55, (1984).
Creighton et al., "Modeling Cortical Cataractogenesis VII: Effects of Vitamin E Treatment on Galactose-Induced Cataracts," Exp. Eye. Res. 40(2):213-22, (1985).
Libondi et al., "In Vitro Effect of Alpha-Tocopherol on Lysophosphatidylcholine-Induced Lens Damage," Exp. Eye. Res. 40(5):661-6, (1985).
Crompton et al., "Aspirin Prevents Carbamylation of Soluble Lens Proteins and Prevents Cyanate-Induced Phase Separation Opacities In Vitro: A Possible Mechanism by Which Aspiring Could Prevent Catarat," Exp. Eye Res. 40(2):297-311, (1985).
Siezen et al., "Permanent Suppression of Phase Separation Cataract in Calf Lenses Using Amine Modification Agents," Biochem. Biophys. Res. Com. 133(1):239-47, (1985).
Siezen and Benedek, "Controlled Modulation of the Ph
Benedek Geroge B.
Clark John I.
Friedman Simon H.
Siezen Roelant J.
Thomson John A.
Fay Zohreh A.
Massachusetts Institute of Technology
LandOfFree
Chemical prevention or reversal of cataract by phase separation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chemical prevention or reversal of cataract by phase separation , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemical prevention or reversal of cataract by phase separation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-577626