Chemical modification of 2"-amino group in elsamicin A

Details Chemical modification of 2"-amino group in elsamicin A Chemical modification of 2"-amino group in elsamicin A

1992-02-13

1993-08-17

Husarik, Nancy S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 181, 536 168, 536 161, 536 186, 536 553, 536124, C07H 506, C07H 1524, C07B 4300

Patent

active

052370550

ABSTRACT:
This invention relates to elsamicin A derivatives wherein the 2"-amino group is selectively modified by acylation or alkylation, a process for producing said elsamicin A derivatives, an antitumor composition containing the same as the active ingredient, and a method for therapy using said compositions.

REFERENCES:
patent: 4439433 (1984-03-01), Heymes et al.
patent: 4472388 (1984-09-01), Umezawa et al.
patent: 4486418 (1984-12-01), Watanabe et al.
patent: 4499083 (1985-02-01), Umezawa et al.
patent: 4515783 (1985-05-01), Linn et al.
patent: 4518589 (1985-05-01), Konishi et al.
patent: 4562177 (1985-12-01), Horton et al.
patent: 4927919 (1990-05-01), Yamada et al.
Katrukha et al.; Chemical Abstracts 105:227282d (1986).
Konishi, et al., J. Antibiotics, 39: 748-791 (1986).
Sugawara, et al., Elsamicins A and B, new antitumor antibiotics related to chartreusin. 2. Structures of elsamicins A and B. J. Org. Chem. 52: 996-1001 (1987).
Leach, et al., Chartreusin, A New Antibiotic Produced by Streptomyces chartreusis, a New Species, J. Am. Chem. Soc. 75: 4011-4012 (1953).
Beisler, J. A., Chartreusin, A glycosideic Antitumor Antibiotic from Streptomyces, Progress in Medicinal Chemistry, Ed., G. P. Ellis and G. B. West 19: pp. 247-268, Elsevier Biomedical Press, Amsterdam, (1982).
Simonitsch et al., Uber die Struktur des Chartreusins I, Helv. Chim. Acta, 47: 1459-1475, (1964).
Eisenhuth, et al., Uber die Struktur des Chartreusins II, Helv. Chim. Acta, 47: 1475-1484, (1964).

Affiliated with

Also associated with

Rating

Chemical modification of 2"-amino group in elsamicin A does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemical modification of 2"-amino group in elsamicin A, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemical modification of 2"-amino group in elsamicin A will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2245136