Chemical methods and intermediates for preparing substituted pyr

Details Chemical methods and intermediates for preparing substituted pyr Chemical methods and intermediates for preparing substituted pyr

1984-09-11

1986-10-28

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544296, 544319, 544333, C07D40106

Patent

active

046200010

ABSTRACT:
A series of chemical reactions starting from the condensation of uracil with an acid stable heterocyclic aldehyde in an acid medium produces biologically active end products which are 2-heterocyclylmethylthioethylamino-5-heterocyclylmethyl-4-pyrimidinones. The new reactions and intermediates of this invention are particularly useful for preparing 2[2-(5-dimethylaminomethyl-2-furylmethylthio)-ethylamino]-5-(6-methyl-3-py ridylmethyl)-4-pyrimidinone and its salts. This compound is a potent H.sub.2 -antagonist with a long duration of activity.

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K. Mori et al., J.C.S. Chem. Comm. (1978), 764.
R. E. Cline et al., J.A.C.S., 81, 2521 (1959).

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