Chemical methods and intermediates for preparing substituted pyr

Details Chemical methods and intermediates for preparing substituted pyr Chemical methods and intermediates for preparing substituted pyr

1981-02-06

1982-10-05

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544123, 544295, 544296, 544310, 544319, 544321, 544333, 544334, C07D40514

Patent

active

043529330

ABSTRACT:
A series of chemical reactions starting from the condensation of uracil with an acid stable heterocyclic aldehyde in an acid medium produces biologically active end products which are 2-heterocyclylmethylthioethylamino-5-heterocyclylmethyl-4-pyrimidinones. The new reactions and intermediates of this invention are particularly useful for preparing 2[2-(5-dimethylaminomethyl-2-furylmethylthio)-ethylamino]-5-(6-methyl-3-py ridylmethyl)-4-pyrimidinone and its salts. This compound is a potent H.sub.2 -antagonist with a long duration of activity.

REFERENCES:
patent: 3932644 (1976-01-01), Durant et al.
patent: 4145546 (1979-03-01), Brown et al.
patent: 4153793 (1979-05-01), Durant et al.
patent: 4154834 (1979-05-01), Brown et al.
patent: 4216318 (1980-08-01), Brown et al.
patent: 4234588 (1980-11-01), Brown et al.

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