Chemical inhibitors of mismatch repair

Details Chemical inhibitors of mismatch repair Chemical inhibitors of mismatch repair

2006-01-03

2006-01-03

Nguyen, Dave Trong (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S254200, C504S357000

Reexamination Certificate

active

06982169

ABSTRACT:
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. Methods of generating mutations in genes of interest and of making various cells mismatch repair defective through the use of chemicals to block mismatch repair in in vivo are disclosed.

REFERENCES:
patent: 4419354 (1983-12-01), Child et al.
patent: 5476952 (1995-12-01), Su et al.
patent: 5885827 (1999-03-01), Wabl et al.
patent: 5907079 (1999-05-01), Mak et al.
patent: 5962249 (1999-10-01), Benton et al.
patent: 6146894 (2000-11-01), Nicolaides et al.
patent: 6191268 (2001-02-01), Liskay et al.
patent: 6287862 (2001-09-01), delCardayre et al.
patent: 2002/0064879 (2002-05-01), Zhang
patent: CA 2 240 609 (1999-10-01), None
patent: WO 97/05268 (1997-02-01), None
patent: 99/19492 (1999-04-01), None
Shiosaki, REv Iberoam Micol 2001: 18:123-127, 2001.
Euler (Caplus Database, AN; 1948:32360, abstract only).
Kimm (Korean J. of Biochemistry, 1982, vol. 14, No. 1, pp. 1-8, abstract).
Laduca, Diss, Abstr Int [B], 55, 11, 4741, 1995, Database CancerLit.
Machala, Mutation Res., 497, 49-62, 2001.
Krahn, Mutation Res., vol. 46, 27-44, 1997.
Wigley, Int. J Cancer, 23, 691-696, 1979.
Slaga, Cancer Res., vol. 38, 1699-1704, 1978.
Hubbard (Mutation Res. 85/4, p. 264, 1981).
Traczewska et al. (Acute Microbiologica Polonica, vol. 40, 3, 4, 235-241, 1991).
LaVoie, Carcinogenesis, vol. 6, pp. 1483-1488, 1985.
Cerniglia et al., Applied and Environmental Microbiology, vol. 56, No. 3, pp. 661-668, 1990.
Lamparczyk, Carcinogenesis, vol. 5, 11:1405-1410, 1984.
Venitt, J. Med, Chem, 41:3748-3752, 1998.
Ngo et al. Computational complexity, protein structure prediction, and the levinthal paradox pp. 490-495-1994.
Hoorn et al. Detection of chemical mutagens using muta mouse: a transgenic mouse model pp. 7-10 1993.
Kotiloglu E. Comparison of target organs of carcinogencity for mutagenic and non-mutagenic chemicals Doga-Turkish Journal of Medical Sciences, 1993 18/2 115-126.
Hachiya et al. Induction of lacZ mutation by 7,12-dimethylbenz[a]anthracene in various tissues of transgenic mice pp. 283-295 1999.
Shelton et al. Mutant frequency and molecular analysis of in vivo laci mutations in the bone marrow of big blue rats treated with 7,12-dimethylbenz[a]anthracene pp. 235-242 2000.
Skolnick et al. From genes to protein structure and function: novel applications of computational approaches in the genomic era pp. 34-39 2000.
Bork Powers and pitfalls in sequence analysis: The 70% hurdle pp. 398-400 2000.
Yamamoto et al. A functional and quantitative mutational analysis of p52 mtations in yeast indicates strand biases and different roles of mutations in DMBA- and BBN-induced tumors in rats pp. 700-705 1999.
Cosma et al. Ha-ras oncogene mutations in cell lines derived from rat tracheal implants exposed in vivo to 7,12-dimethylbenz[a]anthracene pp. 258-263 1990.
Thompson The use of DNA-Repair-Deficient mutants of chinese hamster ovary cells in studying mutagenesis mechanisms and testing for environmental mutagens pp. 217-246 (1983).
Dobrovolsky et al. 7,12-Dimethylbenz[a]anthracene-induced mutation in the Ik gene of Tk=/-Mice: automated scoring of lymphocyte clones using a fluorescent viability indicator pp. 283-291 2000.
Nakazawa et al. Relationship between chemically induced ha-ras mutation and transformation of balb/c 3t3 cells: pp. 202-209 1990.
Honma et al. Cyrotoxic and mutagenic responses to x-rays and chemical mutagens in normal and p53-mutated human lymphoblastoid cells pp. 89-98 1997.
Nelson et al. Detection of mutant ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors pp. 6398-6402 1992.
Proceedings of the american association for cancer research vol. 37, p. 116 1996.
Mironov, N., et al., “Induction of mutations in mismatch repair -proficient and -deficient human colon cancer cell lines by carcinogens producing different types of DNA damage,”Proceedings of the American Association for Cancer Research Annual Meeting,1999, p. 625.
Traczewska, T.M., “Changes of toxicological properties of biodegradation products of anthracene and phenanthrene,”Water Science and Technology,2000, 41(12), 31-38.
Aronshtam, A., et al. “Dominant negative mutator mutations in the mutl gene ofEscherichia coli”, Nucleic Acids Research,1996, 24(13), pp 2498-2504.
Cascalho M, et al. “Mismatch repair co-opted by hpermutation”,Science,1998, 279(20), pp. 1207-1210.
Polaczek, P., et al. “Functional genetic tests of DNA mismatch repair protein activity inSaccharomyces cerevisiae”, Gene,1998, 213(1-2), pp. 159-167.
Kong, Q., “PMS2-deficiency diminishes hypermutation of a λ1transgene in young but not older mice,”Molecular Immunology 36,1999, 83-91.
Schrader, C.E., et al., “Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes,”J. Exp. Med.,1999, 323-330.
Vora, K.A., et al., “Severe attenuation of the B celll immune response in Msh2-deficient mice,”J. Exp. Med.,1999, 189(3), 471-481.
Winter, D.B., et al., “Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2,”Proc. Natl. Acad. Sci. USA,1998, 95, 6953-6958.
Fishel, R., et al., “the human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer,”Cell,1993, 7, 1027-1038.
Hamilton, S.R., et al., “The molecular basis of turcot's syndrome,”N. Eng. J. Med.,1995, 332(13), 839-847.
Nicolaides, N.C., et al., “Molecular cloning of the N-Terminus of GTBP,”Genomics,1996, 31, 395-397.
Parsons, R., et al., “Mismatch repair deficiency in phenotypically normal human cells,”Science,1995, 268, 738-740.
Culligan, K.M., et al., “DNA mismatch repair in plants,”Plant Physiol.,1997, 15, XP-002099372, 833-839.
Jean, M., et al., “Isolation and characterization ofAtMLH1,aMutLhomologue fromArabidopsis thaliana,” Mol. Gen. Genet.,1999, 262, XP-000986138, 633-642.
Lipkin, S.M., et al., “MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability,”Nature Genetics,2000, 24, XP-002165243, 27-35.
Harfe, B.D., “DNA mismtach repair and genetic instability”Annu. Rev. Genet.,2000, 34, 359-399.
Nicolaides, N.C., et al., “Mutations of two PMS homologues in hereditary nonpolyposis colon cancer”Nature,1994, 371, 75-80.
Perucho, M., et al., “Cancer of the microsatellite mutator phenotype”Biol. Chem.,1996, 377, 675-684.
Traczewska, T.M., et al., “The metabolism of anthracene and 9, 10-dimethylanathracene by bacteria isolated from waters,”Acta Microbiologica Polonica,1991, 40(3/4), 235-241.
Chakravarti, D. et al., “Relating aromatic hydrocarbon-induced DNA adducts and c-H-rasmutations in mouse skin papillomas: The role of apurinic sites”,Proc. Natl. Acad. Sci. USA,Oct. 1995, vol. 92, pp. 10422-10426.
Quian, Y. et al., “Molecular events after antisense inhibition of hMSH2 in a HeLa cell line”Mutation Research,Oct. 12, 1998, vol. 418, pp. 61-71.
Yu, Y. et al., “Adriamycin induces large deletions as a major type of mutation in CHO cells”,Mutation Research,Nov. 1994, vol. 325, pp. 91-98.
Allen, D., et al., “MutS mediates heteroduplex loop formation by a translocation mechanism,”EMBO J.,1997, 16(14), 4467-4476.
Baker, S.M., et al., “Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis,”Cell,1995, 82, 309-319.
Bell, C.J., et al., “Assignment of 30 microsatellite loci to the linkage map ofarabidopsis,” Enomics,1994, 19, 137-144.
Bjornson, K., et al., “Modulation of MutS ATP hydrolysis by DNA cofactors,ȁ

Affiliated with

Also associated with

Rating

Chemical inhibitors of mismatch repair does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemical inhibitors of mismatch repair, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemical inhibitors of mismatch repair will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3558702