Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2006-01-03
2006-01-03
Nguyen, Dave Trong (Department: 1632)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S254200, C504S357000
Reexamination Certificate
active
06982169
ABSTRACT:
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. Methods of generating mutations in genes of interest and of making various cells mismatch repair defective through the use of chemicals to block mismatch repair in in vivo are disclosed.
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Grasso Luigi
Nicolaides Nicholas C.
Sass Philip M.
Morphotek Inc.
Nguyen Dave Trong
Woodcock & Washburn LLP
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