Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Aldehyde doai
Patent
1995-11-21
1997-12-09
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Aldehyde doai
514736, 514737, A01N 3500, A01N 3108
Patent
active
056961707
DESCRIPTION:
BRIEF SUMMARY
The invention relates to the use of microbicidal phenolic compounds in combination with glutaraldehyde for the preparation of disinfectants which are suitable for the disinfection of surfaces and instruments, but also of parts of the body (for example hands) in hospitals and doctors' surgeries.
It is known that there is a considerable risk of infection for patients and staff in hospitals and in doctors' surgeries from microorganisms such as bacteria, yeasts and viruses which are pathogenic to humans. Taking into account this risk of infection for patients and staff, the disinfection of surfaces and instruments in hospitals and doctors' surgeries is of particular importance. Apart from the known causative agents of hospitalism from amongst the bacteria and yeasts, viruses have gained increasing importance amongst disinfection procedures.
The requirements regarding the effectiveness of disinfectants are described, for example, in the regulations of the DGHM (Dt. Gesellschaft Health Office!) and the Dt. Vereinigung zur Bekampfung von Disinfectants which meet the DGHM requirements are listed in the VII list as per 1.1.92. Nothing is mentioned as yet in these lists on the virucidal properties of the disinfectants.
When used at concentrations, and over periods, which are relevant under realistic conditions, the combination according to the invention guarantees a greatly reduced number of pathogenic microorganisms amongst bacteria and yeasts and also inactivation of, for example, DVV-listed, naked and enveloped viruses while fully meeting current requirements. The invention is based on a combination of microbicidal phenolic compounds (ph) and glutaraldehyde (glu).
Phenolic active substances for the disinfection of surfaces and instruments of Chemical Engineering!, 4th Edition, 1975, Volume 20, pp. 41-58). It is furthermore known that microbicidal phenolic compounds have an insufficient activity against naked viruses. It is also known that inactivation of naked viruses, such as polio, is made possible by concentration from 1% of glutaraldehyde (10,000 ppm) in alkaline solution.
CA 2.015.079 describes a disinfectant composed of glu, o-phenylphenol, p-tert-amylphenol, sodium arylalkylsulphonate, citric acid and water. A combination of the abovementioned active substances allows stabilization and an activity specifically against bacteria which are pathogenic to humans, even in the acidic range. A virucidal activity is not described. Moreover, this formulation comprises an extremely large amount of glu, which results in odour and corrosion problems and might, under certain circumstances, cause allergic reactions.
The invention therefore relates to the use of a combination of glutaraldehyde and 2-phenyl-phenol and/or para-chloro-meta-cresol for the disinfection of surfaces, instruments and parts of the body.
The combinations according to the invention meet the following requirements as disinfectants: to humans; exist on the surfaces are reduced reliably to a level that meets requirements: optimal effectiveness is achieved using the lowest possible use concentrations, both of phenolic microbicides and of glu; potential of odour nuisance, of a potential sensitization and of discolouring (of the skin) while maintaining full virucidal effectiveness;
The combinations according to the invention are generally in the form of liquid concentrated formulations which are generally used according to the invention after dilution with water.
In general, the concentrates according to the invention comprise 2-20% by weight, preferably 3-15% by weight, and especially 3-12% by weight, of the microbocidal phenolic compounds. If appropriate, the ratio between o-phenylphenol and para-chloro-meta-cresol is 100:0 to 0:100 parts by weight.
Moreover, the concentrates according to the invention comprise 2-50% by weight, preferably 2-10% by weight and especially 2-5% by weight, of glutaraldehyde.
Moreover, the concentrates according to the invention preferably comprise acidifiers, such as citric acid, lactic acid and malic acid to bring the pH of
REFERENCES:
patent: 3917850 (1975-11-01), Boucher
patent: 4654374 (1987-03-01), Martin
patent: 5250573 (1993-10-01), Magni
Martindale, The Extra Pharmacopoeia, 28th edition, pp. 564-565, 558 and 1290, 1982.
Exner Otto
Hoffmann Manfred
Bayer Aktiengesellschaft
Henley III Raymond
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