Chemical derivatives of GHL-Cu

Details Chemical derivatives of GHL-Cu Chemical derivatives of GHL-Cu

1985-02-08

1987-05-12

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, A61K 3702, C07K 508

Patent

active

046650547

ABSTRACT:
Derivatives of GHL-Cu possessing greater resistance to proteolytic enzyme breakdown are disclosed. These derivatives can be tailored to increse their fat solubility, making them more useful in the formation of pharmaceutical creams and gels. Further, the derivatives of the present invention possess significant superoxide dismustase activity, making them useful for enhancing the wound-healing process in animals.

REFERENCES:
The Biological Effects and Mechanism of Action of the Plasma Tripeptide Glycyl-L-histidyl-L-lysine, Loren Pickart, Lymphokines, vol. 8, pp. 425-446.
Stimulation of Rat Peritoneal Mast Cell Migration by Tumor-Derived Peptides, Thomas J. Poole et al., Cancer Research 43, 5857-5861, Dec. 1983.
Ceruloplasmin, Copper Ions, and Angiogenesis, Katari S. Raju et al., JNCI, vol. 69, No. 5, Nov. 1982, pp. 1183-1188.
Structure of the Glycyl-L-histidyl-L-lysine-Copper(II) Complex in Solution, Jonathan H. Freedman et al., reprinted from Biochemistry, 1982, 21, pp. 4540-4544.
PMR Studies of Cu(II) and Zn(II) Interaction with Glycyl-L-histidyl-L-lysine and Related Peptides, Elizabeth Y. Kwa et al., Peptides: Structure and Function 8:805-808 (1983).
The Structure of a Copper Complex of the Growth Factor Glycyl-L-histidyl-L-Lysine at 1.1 .ANG. Resolution, Christopher M. Perkins et al., Inorganica Chimica Acta, 82 (1984), 93-99.

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