Chemical compounds having selective thyromimetic activity

Details Chemical compounds having selective thyromimetic activity Chemical compounds having selective thyromimetic activity

1987-12-21

1989-05-02

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514539, 514544, 514546, 514558, 514562, 514563, 514564, 514568, 514571, 514616, 514618, 514619, 514620, 514622, 558 29, 558 30, 558 32, 558 33, 560 9, 560 18, 560 21, 560 36, 560 40, 560 45, 560 46, 560 55, 560 57, 560 64, 560 65, 560 66, 560105, 560138, 560140, 562426, 562432, 562435, 562441, 562447, 562452, 562453, 562468, 562465, 562473, 562474, 564153, 564154, 564155, 564157, 564158, 564162, 564166, 564167, C07C10172, A61K 3124

Patent

active

048268763

ABSTRACT:
This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinyl-methyl]-thyronine.

REFERENCES:
patent: 3017428 (1962-01-01), Jorgansen
patent: 3410891 (1968-11-01), Hughes
patent: 3477954 (1969-11-01), Reynolds, et al.
Asher, N. L., Current Therapeutic Res., vol. 14, No. 8, pp. 525-539 (Aug. 1972).
The Coronary Drug Project, JAMA, vol. 220, No. 7, pp. 996-1008 (May 1972).
Goldfine, I. D., et al., "Activities of Thyroid Hormones and Related Compounds in an In Vitro Thymocyte Assay", J. Biol. Chem., vol. 251, No. 14, pp. 4233-4238 (1976).
Simon, Z. et al., "Studiu Structura Chimica-Activitate Biologica Pentru Situsul Fixator de Tiroxina al Prealbuminei Umane", Timisoara Med., vol. 26, No. 3, pp. 26-28 (1981).
Gwinup, G. et al., Am. J. Med. Sci., vol. 254, pp. 416-420 (Oct. 1967).
Gharib, H., et al., "Radioimmunoassay for Triiodothyronine (T.sub.3): U, Affinity and Specificity of the Antibody for T.sub.3 ", J. Clin. Endocrinol. Metab., vol. 33, No. 3, pp. 509-516 (Sep. 1971).
Ahmad, P., et al., "Parachors in Drug Design", Biochem. Pharm., vol. 24, No. 10, pp. 1103-1109 (1975).
Korener, D., et al., "Binding of Selected Iodothyronine Analogues to Receptor Cites of Isolated Rat Hepatic Nuclei", J. Biol. Chem., vol. 250, No. 16, pp. 6417-6423 (1975).
Andrea, T. A., et al., "Binding of Thyroid Hormones and Analogues to the Human Plasma Protein Prealbumin", Biochemistry, vol. 19, pp. 55-63 (1980).
Dietrich, S. W., et al., "Thyroxine Analogues, 23 Quantitative Structure-Activity Correlation Studies of In Vivo and In Vitro Thyromimetic Activities", Journal of Medicinal Chemistry, vol. 20, No. 7, pp. 863-880 (Jul. 1977).
Jorgensen, E. C., et al., "The Nature of the Thyroid Hormone Receptor", Int. Congr. Ser.-Excepta Med., 378, Thyroid Res. pp. 303-6 (1976).

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