Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2002-09-23
2008-05-20
Shiao, Rei-tsang (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S304000, C546S339000, C546S340000
Reexamination Certificate
active
07375121
ABSTRACT:
The present invention concerns compounds of formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts,which compounds inhibit carboxypeptidase U and thus can be used in the prevention and treatment of diseases where inhibition of carboxypeptidase U is beneficial. In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt or solvate thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above.
REFERENCES:
patent: 6046180 (2000-04-01), Jackson et al.
patent: 01/19836 (2001-03-01), None
patent: WO-00/66152 (2000-11-01), None
patent: WO-00/66550 (2000-11-01), None
patent: WO-00/66557 (2000-11-01), None
patent: WO-02/14285 (2002-02-01), None
Cross et al., 1983, CAS: 98: 198019.
Wang, W., et al., “Carboxypeptidase U, a Plasma Carboxypeptidase with High Affinity for Plasminogen,” J. of Biol. Chem., 269(22), 15937-15944 (1994).
Hendriks, D., et al., “Purification and characterization of new arginine carboxypeptidase in human serum,” Biochimica et Biophysica Acta, 1034, 86-92 (1990).
Eaton, D., et al., “Isolation, Molecular Cloning, and Partial Characterization of a Novel Carboxypeptidase B from Human Plasma,” J. of Bio. Chem., 266(32), 21833-21838 (1991).
Hendriks, D., et al., “Asay of Carboxypeptidase N Activity in Serum by Liquid-Chromatographic Determination of Hippuric Acid,” Clin. Chem. 31/12, 1936-1939 (1985).
AstraZeneca AB
Morgan & Lewis & Bockius, LLP
Shiao Rei-tsang
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