Chemical compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S303000

Reexamination Certificate

active

10953136

ABSTRACT:
The present invention provides compounds of formula (I)wherein R1and R2are as defined hereinabove.The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.

REFERENCES:
patent: 6855724 (2005-02-01), Basford et al.
patent: WO91/11172 (1991-08-01), None
patent: WO94/02518 (1994-02-01), None
patent: WO95/28401 (1995-10-01), None
patent: WO97/30997 (1997-08-01), None
patent: WO98/55148 (1998-12-01), None
patent: WO 00/35298 (2000-06-01), None
patent: WO 00/38680 (2000-07-01), None
patent: WO 01/90106 (2001-11-01), None
patent: WO 01/90106 (2001-11-01), None
patent: WO 03/084954 (2003-10-01), None
Cascieri, M., et al. “The Chemokine/Chemokine Receptor Family: Potential And Progress For Therapeutic Intervention,”Curr. Opin. Chem. Biol., 2000, 420-427, vol. 4, No. 4.
Cavero, I., et al., “Drugs That Prolong QT Interval As An Unwanted Effect: Assessing Their Liikelihood Of Inducing Hazardous Cardiac Dysryhthmias,”Expert Opinion Of Pharmacotherapy, 2000, 947-973, vol. 1, No. 5.
Combadiere, C., et al. “Cloning And Functional Expression Of CC CKR5, A Human Monocyte CC Chemokine Receptor Selective For MIP-1α, MIP-1β, And RANTES,”Journal of Leukocyte Biology, 1996, 147-152, vol. 60.
Finnin, B., et al., “Transdermal Penetration Enhancers: Applications, Limitations, And Potential,”Journal Of Pharmaceutical Sciences, 1999, 955-958, vol. 88, No. 10.
Green, T., et al.,Protective Groups In Organic Synthesis, 3rdEdition, 1999, 494-653, John Wiley and Sons.
Haleblian, J., “Characterization Of Habits And Crystalline Modification Of Solids And Their Pharmaceutical Applications,”Journal of Pharmaceutical Science, 1975, 1269-1288, vol. 64, No. 8.
Liang, et al., “Fast-Dissolving Intraoral Drug Delivery Systems,”Expert Opinion In Therapeutic Patents, 2001, 981-986, vol. 11, No. 6.
March, J.,Advanced Organic Chemistry, 4thEdition, 1992, 352, Wiley Interscience.
March, J.,Advanced Organic Chemistry, 4thEdition, 1992, 652, Wiley Interscience.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chemical compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemical compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemical compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3875789

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.