Chemical compounds

Details Chemical compounds Chemical compounds

2007-04-03

2007-04-03

McKenzie, Thomas (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S382000, C546S342000, C560S126000

Reexamination Certificate

active

10518778

ABSTRACT:
A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof,Wherein:R1and R2are independently hydrogen or C1-3alkyl;X represents a bond, CH2or O;R3and R4are independently hydrogen, C1-6alkyl, OCH3, CF3, allyl or halogen;X1is CH2, SO2, or CO;R5is —C1-6alkyl (optionally substituted by C1-6alkoxy or C1-6alkylthio), —C2-6alkenyl, —C0-6alkyl phenyl (wherein the phenyl is optionally substituted by one or more CF3, halogen, C1-3alkyl, C1-3alkoxy), —COC1-6alkyl, SO2C1-6alkyl;R6is phenyl or a 6 membered heteroaryl group containing 1, 2 or 3 N atoms wherein the phenyl or heteroaryl group is optionally substituted with 1, 2 or 3 moieties selected from the group consisting of C1-6alkyl, halogen, —OC1-6alkyl, —SO2C1-3alkyl, phenyl (optionally substituted by one or more groups selected from halogen, CF3, C1-3alkyl, OC1-3alkyl, acetyl, CN).

REFERENCES:
patent: 3912756 (1975-10-01), Wolff et al.
patent: 4214094 (1980-07-01), Kamiya et al.
patent: 2273518 (1976-01-01), None
patent: WO 00/23407 (2000-04-01), None
patent: 1067109 (2001-01-01), None
patent: WO 02/28821 (2002-04-01), None
Hcaplus 68:49243.
Hcaplus 86:55153.

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