Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-07-03
2007-07-03
Stockton, Laura L. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S388000
Reexamination Certificate
active
10433128
ABSTRACT:
Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
REFERENCES:
patent: 5447860 (1995-09-01), Ziegler
patent: 5624947 (1997-04-01), Keown et al.
patent: 5877020 (1999-03-01), Alitalo
patent: 6030831 (2000-02-01), Godowski et al.
patent: 98/52558 (1998-11-01), None
patent: 98/52559 (1998-11-01), None
patent: 99/24035 (1999-05-01), None
patent: 99/32106 (1999-07-01), None
patent: 99/32110 (1999-07-01), None
patent: 99/32111 (1999-07-01), None
patent: 99/32436 (1999-07-01), None
patent: 99/32455 (1999-07-01), None
patent: 99/32463 (1999-07-01), None
patent: 00/41669 (2000-07-01), None
Isner, J.M. et al., “Therapeutic Angiogenesis,”Fontiers in Bioscience, 3, pp. 49-69, May 5, 1998.
Martiny-Baron, G., German DFG Priority Grant “Angiogenesis” SPP 1069, year not available.
Tyurina , L.A.. et al., “Relations between the structure and embryotoxic action of nitrogen-and sulfur-containing organic compounds,”Khimiko-Farmatsevticheskii Zhurnal(1998), 32(2), pp. 21-27.
Siemeister, G. et al., “Two Independent Mechanisms Essential for Tumor Angiogenesis: Inhibition of Human Melanoma Xenograft Growth by Interfering with either the Vascular Endothelial Growth Factor Receptor Pathway or the Tie-2 Pathway,”Cancer Research, 59, pp. 3185-3191, Jul. 1, 1999.
Schnurch, H. et al., Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage,Development, 119, pp. 957-968 (1993).
Yancopoulos, G.D. et al., “Vasculogenesis, Angiogenesis, and Growth Factors: Ephrins Enter the Fray at the Border,”Cell, vol. 93, pp. 661-664, May 29, 1998.
Peters, Kevin G., “Vascular Endothelial Growth Factor and the Angiopoietins Working Together to Build a Better Blood Vessel,”American Heart Association, Inc., 83, pp. 342-343 (1998).
Tyrina, L.A., et al., “Investigation of the Relationship Between the Structure of Nitrogen-and Sulphur-Containing Organic Compounds and Their Embryotoxic Action,”Konnekthnb astopos(1998), pp. 21-27.
Cheung Mui
Harris Philip Anthony
Hasegawa Masaichi
Ida Satoru
Kano Kazuya
Fox Jennifer L.
Lemanowicz John L.
Smithkline Beecham Corporation
Stockton Laura L.
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