Chemical compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S365000

Reexamination Certificate

active

07119092

ABSTRACT:
whereinR represents a halogen atom or a C1-4alkyl group;R1represents a C1-4alkyl group;R2represents hydrogen or a C1-4alkyl group;R3represents hydrogen, or a C1-4alkyl group;R4represents a trifluoromethyl group;R5represents hydrogen, a C1-4alkyl group or C(O)R6;R6represents C1-4alkyl, C3-7cycloalkyl, NH(C1-4alkyl) or N(C1-4alkyl)2;m is zero or an integer from 1 to 3;n is an integer from 1 to 3 and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation and their use in the treatment of conditions mediated by tachykinins.

REFERENCES:
patent: 4087424 (1978-05-01), Saikawa et al.
patent: 4110327 (1978-08-01), Saikawa et al.
patent: 4112090 (1978-09-01), Saikawa et al.
patent: 4219554 (1980-08-01), Saikawa et al.
patent: 4308387 (1981-12-01), Bjork et al.
patent: 4327097 (1982-04-01), Saikawa et al.
patent: 4379152 (1983-04-01), Saikawa et al.
patent: 4410522 (1983-10-01), Saikawa et al.
patent: 5028610 (1991-07-01), Hirai et al.
patent: 5109014 (1992-04-01), Jacobson
patent: 5334606 (1994-08-01), MacLeod
patent: 5348955 (1994-09-01), Greenlee et al.
patent: 5360820 (1994-11-01), Hagan et al.
patent: 5464788 (1995-11-01), Bock et al.
patent: 5538982 (1996-07-01), Hagan et al.
patent: 5563127 (1996-10-01), Amparo et al.
patent: 5576317 (1996-11-01), Gonsalves
patent: 5696123 (1997-12-01), Dollinger et al.
patent: 5698538 (1997-12-01), Amparo et al.
patent: 5708006 (1998-01-01), Dollinger et al.
patent: 5710169 (1998-01-01), Russell
patent: 5716942 (1998-02-01), Dorn et al.
patent: 5756504 (1998-05-01), Bock et al.
patent: 5814636 (1998-09-01), Katano et al.
patent: 5859015 (1999-01-01), Graham et al.
patent: 5883096 (1999-03-01), Lowe et al.
patent: 5935951 (1999-08-01), Ofner et al.
patent: 5952315 (1999-09-01), Baker et al.
patent: 5977104 (1999-11-01), Baker et al.
patent: 5985881 (1999-11-01), Dollinger et al.
patent: 5998444 (1999-12-01), Russell
patent: 6037352 (2000-03-01), Lowe et al.
patent: 6057323 (2000-05-01), Zhang et al.
patent: 6090807 (2000-07-01), Hellendahl et al.
patent: 6114315 (2000-09-01), Baker et al.
patent: 6117855 (2000-09-01), Carlson et al.
patent: 6147083 (2000-11-01), Russell
patent: 6191135 (2001-02-01), Dollinger et al.
patent: 6191139 (2001-02-01), Hagan
patent: 6197772 (2001-03-01), Janssens et al.
patent: 6235732 (2001-05-01), Dollinger et al.
patent: 6288068 (2001-09-01), Lowe et al.
patent: 6319953 (2001-11-01), Carlson et al.
patent: RE37886 (2002-10-01), Janssens et al.
patent: 6521621 (2003-02-01), Janssens et al.
patent: 6642240 (2003-11-01), Alvaro et al.
patent: 2002/0103205 (2002-08-01), Lowe et al.
patent: 2519400 (1978-04-01), None
patent: 287734 (1987-10-01), None
patent: 293532 (1987-10-01), None
patent: 0655442 (1995-05-01), None
patent: 718287 (1995-12-01), None
patent: 0721941 (1996-07-01), None
patent: 0655422 (2001-05-01), None
patent: 1508062 (1975-04-01), None
patent: 57/118587 (1982-07-01), None
patent: WO 92/16211 (1992-10-01), None
patent: WO 95/00498 (1995-01-01), None
patent: WO 95/25443 (1995-09-01), None
patent: WO 96/02503 (1996-02-01), None
patent: WO 96/03378 (1996-02-01), None
patent: WO 96/10562 (1996-04-01), None
patent: WO 96/14844 (1996-05-01), None
patent: WO 96/20173 (1996-07-01), None
patent: WO 97/16440 (1997-05-01), None
patent: WO 97/32865 (1997-09-01), None
patent: WO 97/36592 (1997-10-01), None
patent: WO 97/36593 (1997-10-01), None
patent: WO 97/36888 (1997-10-01), None
patent: WO 97/36889 (1997-10-01), None
patent: WO 98/01133 (1998-01-01), None
patent: WO 98/20001 (1998-05-01), None
patent: WO 98/57954 (1998-12-01), None
patent: WO 99/09985 (1999-03-01), None
patent: WO 99/26921 (1999-06-01), None
patent: WO 01/025219 (2001-04-01), None
patent: WO 02/032867 (2002-04-01), None
patent: WO 02/057233 (2002-07-01), None
patent: WO 04/033428 (2004-04-01), None
Rupniak et al., “Differential Inhibition of foot tapping and chromodacryorrhoea in gerbils by CNS penetrant and non-penetrant tachykinin NK1receptor antagonists,”European Journal of Pharmacology265:179-183 (1994).
Megens, A., et al. J. Pharmacology and Experimental Therapeutics (2002)302(2):696-709.
Challet, E., et al. Neuropharmacology (2001) 40(3): 408-415.
Romerio, et al., Clinical Pharmacology and Therapeutics (1999) 66(5):522-527.
Davis, David T., “Synthesis A. Biological Activity of a Series of Piperazin-2,3-Diones,” Journal of Antibiotics, vol. XLII, No. 3, 1989, pp. 367-373.
Pacher, P., et al. “Review of Cardiovascular Effects of Fluoxetine, A Selective Serotonine Reuptake Inhibitor, Compared to Tricyclic Antidepressants.” Current Medicinal Chemistry, 1998, 5, pp. 381-390.

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