Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-03-21
2006-03-21
Tsang, Cecilia (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S113000
Reexamination Certificate
active
07015231
ABSTRACT:
The present invention is related to aza-oxindole derivatives, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
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patent: WO 9921859 (1999-05-01), None
patent: 00/08202 (2000-02-01), None
Wood et al. Bioorganic & Medicinal Chemistry Letters. 2004. 14:953-957.
Lackey Karen Elizabeth
Wood, III Edgar Raymond
Hoffman Lexington A.
Lemanowicz John L.
SmithKline Beecham Corporation
Tsang Cecilia
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