Chemical compounds

Details Chemical compounds Chemical compounds

1981-04-30

1982-12-21

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 45, 424243, A61K 3156

Patent

active

043649238

ABSTRACT:
An antiinflammatory steroid exhibiting a tendency to crystal growth in suspension in aerosol propellants is contacted with a halogenated hydrocarbon to form a crystalline solvate, which, after removal of some or all of the propellant from the crystals, is reduced to a particle size permitting inhalation into the human bronchial system when dispersed as an aerosol, the micronised crystalline solvate not thereafter exhibiting crystal growth in the aerosol propellant. The solvate is a new composition of matter which has been characterized by I.R. spectra and the aerosol formulation prepared therefrom has valuable therapeutic properties, particularly in the treatment of asthma.

REFERENCES:
patent: 3312590 (1967-04-01), Elks et al.
patent: 3721687 (1973-03-01), Elks et al.
Brown et al., "British Medical Journal" of Mar. 4, 1972, pp. 585-589.
Mesley, "Chemistry and Industry" dated Sep. 11, 1965, pp. 1594-1595.

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