Chemical compounds

Details Chemical compounds Chemical compounds

1979-08-24

1981-02-10

Howard, Jacqueline V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

424 5, C07C10326

Patent

active

042501130

ABSTRACT:
Compounds of the formula: ##STR1## wherein R represents the group --CH.sub.2 CH.sub.2 OH or --CH.sub.2 CHOHCH.sub.2 OH, particularly in racemic or optically active form, are employed as active ingredients in X-ray contrast agents for intracerebral, but particularly for vascular use. The compounds are prepared by reacting 5-(N-acetamido)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide or an O-acetyl derivative thereof with an appropriate hydroxyalkylating agent and subsequently, if necessary, hydrolysing any unwanted O-acetyl groups.

REFERENCES:
patent: 3701771 (1972-10-01), Almen et al.
patent: 4021481 (1977-05-01), Almen et al.

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