Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-09-16
2000-11-07
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514277, 514279, 514284, 514287, 514359, A61K 3144
Patent
active
061437573
ABSTRACT:
Compounds of the general structural formula ##STR1## and use of the compounds and salts and solvates thereof, as therapeutic agents.
REFERENCES:
patent: 3644384 (1972-02-01), Schulenberg
patent: 3717638 (1973-02-01), Schulenberg
patent: 3917599 (1975-11-01), Saxena et al.
patent: 4188390 (1980-02-01), Campbell
patent: 4686228 (1987-08-01), Campbell et al.
patent: 4801587 (1989-01-01), Voss et al.
patent: 5145852 (1992-09-01), Virag
patent: 5270323 (1993-12-01), Milne, Jr. et al.
patent: 5770606 (1998-06-01), El-Rashidy et al.
patent: 5859006 (1999-01-01), Daugan
patent: 5874437 (1999-02-01), Garvey et al.
patent: 5981527 (1999-11-01), Daugan et al.
A. Bowman et al., Br. J. Pharmac., (1984), 81, 665-674.
F. Trigo-Rocha et al., Am. J. Physiol., (Feb. 1993), 264, H419-H422.
J. Reiser et al., Br. J. Dis. Chest, (1986), 80, 157-163.
P. Bush et al., J. Urol., (Jun. 1992), 147, 1650-1655.
F. Holmquist et al., J. Urol. (Oct. 1993), 150, 1310-1315.
R. Rudd et al., Br. J. Dis. Chest, (1983), 77, 78-86.
E. McMahon et al., J. Pharmacol. Exp. Thera., (1989), 251, 1000-1005.
F. Holmquist et al., Acta Physiol. Scand., (1991), 143, 299-304.
G. Barbanti Urol. Res., (1988), 16, 299-302.
L. Ignarro et al., Biochem. and Biophys. Res. Commun., (1990), 170(2), 843-850.
J. Krall et al., Bio. Reprod., (1988), 39, 913-922.
M. Wilkins et al., Proc. Natl. Acad. Sci., USA, (Aug. 1990), 87, 6465-6469.
M. Wilkins et al., J. Clin. Invest., (Apr. 1990), 85, 1274-1279.
J. Rajfer, N. Eng. J. Med., (Jan. 1992), 326(2), 90-94.
H. Knispel, Urol. Res., (1992), 20, 253-257.
G. Gwinup, Annals. of Internal Medicine, (Jul. 1988), 162-163.
Z. Zorgniotti, J. Urol., (Apr. 1992), 147(4), 308A.
K. Azadzoi et al., J. Urol., (Nov. 1992), 148, 1587-1591.
K. Azadzoi et al., J. Urol., (Jan. 1992), 147, 220-225.
C. Sparwasser et al., J. Urol., (Dec. 1994), 152, 2159-2163.
T. Lue, "Campbell's Urology," 6th Ed., Chap. 16, P. Walsh et al., Eds., W.B. Saunders Co., 709-728 (1991).
N. Kim et al., J. Clin. Invest., (1991), 88, 112-118.
S. Francis et al., in J. Beavo et al. eds. "Cyclic Nucleotide PDEs" Ch. 5 (1990) 117-140.
R. Weishaar et al., J. Med. Chem., (1985), 28:5, 537-542.
H. Ahn et al., Biochem. Pharmacol., (1989), 39:19, 3331-3339.
C. Lugnier et al., Biochem. Pharmacol., (1986), 35:10, 1743-1751.
J. Doremieux et al., Ann. Urol. Paris, (1987), 21(6), 429-434.
D. Green et al., Geriatrics, (Jan. 1993), 48(1), 46-58.
M. Webster et al., Hematol. Oncol. Cl. of N. Am., (Feb. 1990), 4(1), 265-289.
F. Holmquist et al., Acta. Physiol. Scand., (1991), 141, 441-442.
J. Taher et al., J. Urol., (Apr. 1993), 149, 285A.
S. Uckert et al., J. Urol., 151 (5 Supp.), (1994), 495A.
W. Aronson et al., J. Urol., (1991), 145 (4 Supp.), 341A.
P. Bush et al., Fed. Am. Soc. Exp. Biol., (1991), 5(4), 175.
P. Bush et al., Fed. Am. Soc. Exp. Biol., (1992), 6(4), 2092.
W. Aronson et al., J. Urol., (1992), 147 (4 Supp.), 454A.
P. Bush et al., Circulation, (May 1993), 87 Supp. V, V-30-V-32.
R. Pickard et al., J. Urol., (May 1993), 149 (4 Supp.), 245A.
R. Pickard et al., Clin. Pharmacol., (Jan. 1993), 35(5), 536P-537P.
F. Trigo-Rocha et al., J. Urol., (Apr. 1993), 149, 872-877.
M. Krupp et al., J. Cardiovas. Pharmacol., (1989), 13 (Supp.2), S11-S19.
"Physicians' Desk Reference," (1992), 683, 1099-1100, 1344, 1941-1943.
R. Morales et al., World J. Urol., (1990), 8, 80-83.
J. Cortijo, Br. J. Pharmacol., (Feb. 1993), 108(2), 562-568.
E. Kim et al., J. Urol., (1995), 153, 361-365.
S. Korenman et al., JAGS, (Apr. 1993), 41(4), 363-366.
K. Allenby et al., Angiology, (1991), 42, 418-420.
H. Hamilton et al., J. Med. Chem., (1987), 30, 91-96.
H. Padma-Nathan et al., Sem. in Urol., (Nov. 1986), vol. IV, No. 4, 236-238.
J. Beavo et al., TiPS, (Apr. 1990), 11, 150-155.
S. Korenman et al., Clin. Res., (1988), 36, 123A.
D. Halsted et al., J. Urol., (Jul. 1986), 136, 109-110.
W. Thompson, Pharmac. Ther., (1991), 51, 13-33.
M. Giembycz et al., Clin. and Exper. Allergy, (1992), 22, 337-344.
C. Nicholson et al., TIPS, (Jan. 1991), 12, 19-27.
J. LeBlanc et al., Eur. J. Cardiothorac Surg., (1993), 7, 211-215.
C. Stief et al., J. Urol., (Nov. 1992), 148, 1437-1440.
C. Stief et al., World J. Urol., (1991), 9, 237-239.
C. Clyne et al., Br. J. Surg., (Apr. 1987), 74, 246-248.
V. Mirone et al., Acta Urol. Ltd., (1992), Suppl. 4, 11-12.
P. Bush, Ph.D. Thesis (1992), pp. 159-160.
T. Lincoln, Pharmac. Ther., (1989), 41, 479-502.
J. Heaton et al., Urology, (Feb. 1995), 45(2), 200-206.
Saxena et al., Journal of Medicinal Chemistry, vol. 16, No. 5, 560-564 (1973).
Ishida et al., Chem. Pharm. Bull., vol. 33, No. 8, 3237-3249 (1985).
Gillespie et al., Molecular Pharmacology, 36:773-781 (1989).
Brana et al., Synthetic Communications, 20(12), 1793-1820 (1990).
Dellouve-Courillon et al., Tetrahedron, 46, No. 9, 3245-3266 (1990).
Murray, DN&P 6(3), 150-156 (1993).
Zorgniotti et al. Int. J. Impotence Res., 6, 33-36 (1994).
Beyer et al., Phys. and Behav., (1981), 27, 731-733.
Pickard et al., Br. J. Pharmacol., (1991), 104 755-759.
Martinez-Pineiro et al., Eur. Urol., (1992), 24, 492-499.
Mirone et al., Br. J. Urol., (Mar. 1993), 71(3), 365.
Murray et al., Biochemical Soc. Trans., (1992), 20, 460-464.
Raeburn et al., Prog. Drug Res., (1993), 12-32.
Merkel, Cardio. Drug. Rev., (1993), 11(4), 501-515.
"Physicians' Desk Reference," (1992), 2207-2208.
Cimino et al., Biochem. Pharmacology, (1988), 37(14), 2739-2745.
Watanabe et al., Federation Proceedings, (1982), 41(7), 2292-2399.
Earl et al., Life Sciences, (1984), 35, 525-534.
Brindley, Brit. J. Phychiat., (1993), 143, 332-337.
Keogh, Aust. NZ. J. Med., (1989), 19, 108-112.
Funderbunk, New Engl. J. Med., (1974), 290, 630-631.
Beretta, Acta European Fertilitatis, (1986), 17, 43-45.
"Physicians' Desk Reference," (1992), 1778-1779.
Hess in "Prazosin: Evaluation of a New Antihypertensive Agent," D. Cotton ed., American Elsevier, NY, (1974), 3-15.
Dadkar et al., Ind. J. Exp. Biol., (1982), 20, 484-487.
D'Armiento et al., Eur. J. Pharmacol., (1980), 65, 234-247.
Bhalla et al., Brit. Med. J., (1979), 2, 1059.
Burke et al., Med. J. Aust., (1980), 382-383.
Segasouthy et al., Med. J. Malaysia, (1982), 37(4), 384.
Ylitalo et al., Acta Med. Scand., (1983), 213, 319-320.
Robbins et al., J. Urol., (1983), 130, 975.
Adams et al., J. Urol., (1984), 132, 1208.
Russell et al., Med. J. Aust., (1985), 143, 321.
Taher et al., Int. J. Impotence Res., Abstracts, Milan, Italy (Sep. 14-17, 1992).
Trigo-Rocha et al., Neurology and Urodynamics, 13, (1998) 71-80.
Lopez-Rodriguez et al., Chemical and Pharmaceutical Bulletin, vol. 43, No. 6 (Jun. 1995) pp. 941-946.
Miguel et al., Journal of Heterocyclic Chemistry, vol. 31, No. 5 (1994) pp. 1235-1239.
Lopez-Rodriguez et al., Journal of Organic Chemistry, vol. 59, No. 6 (1994) pp. 1583-1595.
Brana et al., Journal of Heterocyclic Chemistry, vol. 27, No. 3 (1990) pp. 703-706.
Sandrin et al., Heterocycles, vol. 4, No. 7 (1976) pp. 1249-1255.
Brana et al., Liebigs Annalen der Chemie, No. 8, (1992) pp. 867-869.
Daugan Alain Claude-Marie
LaBaudiniere Richard Frederick
Cintins Marianne M.
Delacroix-Muirhead C
ICOS Corporation
LandOfFree
Chemical compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chemical compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemical compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1641406