Chemical compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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560135, 560136, 560137, 564 15, 564162, 564180, C07C26100, C07C32100, C07F 902

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active

054059909

ABSTRACT:
Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.

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