Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-10-31
2011-11-22
Davis, Zinna Northington (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S201000
Reexamination Certificate
active
08063071
ABSTRACT:
The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I:where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof.The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
REFERENCES:
patent: 4775761 (1988-10-01), Strupczewski
patent: 5026856 (1991-06-01), Yatsunami et al.
patent: 5254473 (1993-10-01), Patel
patent: 5256673 (1993-10-01), Böttcher et al.
patent: 5330986 (1994-07-01), Shutske
patent: 6245799 (2001-06-01), Asselin et al.
patent: 6358994 (2002-03-01), Fritz et al.
patent: 6509340 (2003-01-01), Van Amsterdam et al.
patent: 6589954 (2003-07-01), Mavunkel et al.
patent: 6919335 (2005-07-01), Iwanowicz et al.
patent: 2002/0103229 (2002-08-01), Bhagwat et al.
patent: 2002/0147189 (2002-10-01), Cai et al.
patent: 2002/0161004 (2002-10-01), Browner et al.
patent: 2003/0022898 (2003-01-01), Burke et al.
patent: 2005/0153966 (2005-07-01), Gangloff et al.
patent: 2005/0165086 (2005-07-01), Callahan et al.
patent: 2006/0116419 (2006-06-01), Callahan et al.
patent: 2006/0062058 (2006-12-01), Kerns
patent: 2007/0254873 (2007-11-01), Kerns et al.
patent: 2007/0281933 (2007-12-01), Kerns et al.
patent: 2008/0146606 (2008-06-01), Bamborough et al.
patent: 2008/0242685 (2008-10-01), Kerns et al.
patent: 2008/0262040 (2008-10-01), Callahan et al.
patent: 2008/0269291 (2008-10-01), Kerns et al.
patent: 2008/0293802 (2008-11-01), Kerns et al.
patent: 2009/0030014 (2009-01-01), Kugimiya et al.
patent: 2009/0143372 (2009-06-01), Kerns et al.
patent: 2010/0130468 (2010-05-01), Busch-Petersen et al.
patent: 2010/0179139 (2010-07-01), Bamborough et al.
patent: 3342632 (1985-06-01), None
patent: 19500689 (1996-07-01), None
patent: 19807993 (1999-09-01), None
patent: 19928424 (2000-12-01), None
patent: 10112151 (2002-09-01), None
patent: 10259244 (2004-07-01), None
patent: 279263 (1993-08-01), None
patent: 0556949 (1993-08-01), None
patent: 610134 (1994-08-01), None
patent: 416609 (1997-01-01), None
patent: 0812826 (1997-12-01), None
patent: 1077213 (2001-02-01), None
patent: 1134221 (2001-09-01), None
patent: 1209158 (2002-05-01), None
patent: A-60-132980 (1985-07-01), None
patent: A-2002-533333 (2002-10-01), None
patent: WO94/21627 (1994-09-01), None
patent: WO 94/21627 (1994-09-01), None
patent: WO94/21630 (1994-09-01), None
patent: WO96/40115 (1996-12-01), None
patent: WO97/44319 (1997-11-01), None
patent: WO98/06715 (1998-02-01), None
patent: WO98/28292 (1998-07-01), None
patent: WO99/43652 (1999-02-01), None
patent: WO99/17773 (1999-04-01), None
patent: WO00/00487 (2000-01-01), None
patent: WO01/00610 (2001-01-01), None
patent: WO01/30774 (2001-05-01), None
patent: WO01/34598 (2001-05-01), None
patent: WO 01/83472 (2001-05-01), None
patent: WO01/58890 (2001-08-01), None
patent: WO01/68648 (2001-09-01), None
patent: WO01/83472 (2001-11-01), None
patent: WO01/87298 (2001-11-01), None
patent: WO01/98290 (2001-12-01), None
patent: WO02/14317 (2002-02-01), None
patent: WO02/16353 (2002-02-01), None
patent: WO 02/16353 (2002-02-01), None
patent: WO02/24679 (2002-03-01), None
patent: WO02/24693 (2002-03-01), None
patent: WO02/28860 (2002-03-01), None
patent: WO02/30353 (2002-04-01), None
patent: WO02/30423 (2002-04-01), None
patent: WO02/41843 (2002-05-01), None
patent: WO02/44153 (2002-06-01), None
patent: WO02/46171 (2002-06-01), None
patent: WO02/051837 (2002-07-01), None
patent: WO02/060386 (2002-08-01), None
patent: WO02/094265 (2002-11-01), None
patent: WO02/094322 (2002-11-01), None
patent: WO02/094813 (2002-11-01), None
patent: WO03/007076 (2003-01-01), None
patent: WO03/010158 (2003-02-01), None
patent: WO03/010163 (2003-02-01), None
patent: WO03/022898 (2003-03-01), None
patent: WO03/024935 (2003-03-01), None
patent: WO03/024936 (2003-03-01), None
patent: WO03/027075 (2003-04-01), None
patent: WO 03/035625 (2003-05-01), None
patent: WO03/037664 (2003-05-01), None
patent: WO 03/037886 (2003-05-01), None
patent: WO03/037886 (2003-05-01), None
patent: WO03/068193 (2003-08-01), None
patent: WO03/084959 (2003-10-01), None
patent: WO03/087087 (2003-10-01), None
patent: WO03/095430 (2003-11-01), None
patent: WO03/101987 (2003-12-01), None
patent: WO03/103661 (2003-12-01), None
patent: WO03/104218 (2003-12-01), None
patent: WO2004/019935 (2004-03-01), None
patent: WO2004/022553 (2004-03-01), None
patent: WO2004/024730 (2004-03-01), None
patent: WO2004/024732 (2004-03-01), None
patent: WO2004/024736 (2004-03-01), None
patent: WO2004/047760 (2004-06-01), None
patent: WO2004/075846 (2004-09-01), None
patent: WO 2004/089913 (2004-10-01), None
patent: WO2004/089913 (2004-10-01), None
patent: WO2004/106293 (2004-12-01), None
patent: WO2005/012283 (2005-02-01), None
patent: WO2005/035527 (2005-04-01), None
patent: WO2005/035537 (2005-04-01), None
patent: WO 2005/067923 (2005-07-01), None
patent: WO2005/067923 (2005-07-01), None
patent: WO 2006/002434 (2006-01-01), None
patent: WO2006/002434 (2006-01-01), None
patent: WO 2006/034317 (2006-03-01), None
patent: WO2006/034317 (2006-03-01), None
patent: WO2006/106326 (2006-10-01), None
patent: WO2007/005534 (2007-01-01), None
patent: WO2007/010964 (2007-01-01), None
patent: WO2007/114848 (2007-10-01), None
patent: WO2009/112473 (2009-09-01), None
patent: WO2010/102968 (2010-09-01), None
patent: WO2010/106016 (2010-09-01), None
Wermuth, C.G.,The Practice of Medicinal Chemistry, Academic Press, pp. 203-214 (1996).
U.S. Appl. No. 10/597,154, filed Jul. 13, 2006, Baldwin et al.
U.S. Appl. No. 11/570,060, filed Dec. 5, 2006, Jeffrey K. Kerns.
U.S. Appl. No. 11/575,416, filed Mar. 16, 2007, Kerns et al.
U.S. Appl. No. 12/532,773, filed Mar. 20, 2008, Jeffrey K. Kerns.
Aupperle et al., “NF-κB Regulation by IκB Kinase in Primary Fibroblast-Like Synoviocytes”J. Immunology(1999) 163:427-433.
Aupperle et al., “NF-κB Regulation by IκB Kinase-2 in Rheumatoid Arthritis Synoviocytes”J. Immunology(2001) 166:31496-31501.
Breton et al., “The Natural Product Hymenialdisine Inhibits Interleukin-8 Production in U937 Cells by Inhibition of Nuclear Factor-κB”JPET(1997) 282(1):459-466.
Burke et al., “BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice”J. Biol Chem. (2003) 278:1450-1456.
Guttridge et al., “NF-κB-Induced Loss ofMyoDMessenger RNA: Possible Role in Muscle Decay and Cachexia”Science(2000) 289:2363-2365.
Murata et al., “Discovery of novel and selective IKK-β serine-threonine protein kinase inhibitors. Part 1.”Bioorg. Med. Chem. Letter(2003) 13:913-198.
Murata et al., “Synthesis and structure—activity relationships of novel IKK-β inhibitors. Part 2: Improvement of in vitro activity”Bioorg. Med. Chem. Letter(2004) 14(15):4013-4017 and “Synthesis and structure—activity relationships of novel IKK-β inhibitors. Part 3: Orally active anti-inflammatory agents,”Bioorg. Med. Chem. Letter(2004) 14(15):4019-4022.
Peet et al., “IκB Kinases α and β Show a Random Sequential Kinetic Mechanism and Are Inhibited by Staurosporine and Quercetin”J. Biol. Chem. (1999) 274:32655-32661.
Pierce, et al., “Novel Inhibitors of Cytokine-induced IκBα Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effectsin Vivo” J. Biol. Chem. (1997) 272
Jin Qi
Kerns Jeffrey K.
Lindenmuth Michael
Thomas Sonia M
Widdowson Katherine L.
Davis Zinna Northington
Furman Theodore R.
GlaxoSmithKline LLC
Stein Nora L.
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