Chemical Compound

Details Chemical Compound Chemical Compound

1994-01-04

1995-05-23

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

514774, 530353, 530840, 623 16, A61K 914, A61K 4742, A61K 3712

Patent

active

054179750

ABSTRACT:
The invention provides a process for the preparation of high purity bone mineral wherein the organic matter in degreased bone is degraded and solubilized by heating with ammonia or a primary amine, characterized in that the solubilized degradation products are extracted by washing with flowing water at temperatures below 60.degree. C., such heating with primary amine and washing steps optionally being repeated, whereby substantially all organic matter removable by these steps is removed, the bone mineral so treated being heated in air at temperatures of up to 700.degree. C.

REFERENCES:
patent: 4596574 (1986-06-01), Urist
patent: 4880610 (1989-11-01), Constantz
Merck Index, entry 4276, p. 685.
Merck Index, entry 1701, p. 276.
Ganong, MD, Review of Medical Physiology, "A Lange Medical Book", 13th Ed. 1987, pp. 322-323.
Klinge et al., "Osseous Response to Implanted Natural Bone Mineral and Synthetic Hydroxylapatite Ceramic in the Repair of Experimental Skull Bone Defects," J. Oral Maxillofac Surg. 50:241-249, (1992).
Spector, M., "Analogs of Bone Mineral as Implants to Facilitate Bone Regeneration," Proc. Portland Bone Symposium, Jul. 21-24, 1993.

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