Chemical biochemical and biological processing in thin films

Details Chemical biochemical and biological processing in thin films Chemical biochemical and biological processing in thin films

1995-06-05

1998-07-07

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 5, 435 911, 435 71, 435 72, 435 79, 436172, 436518, 436527, 436543, 436547, 356364, 536 243, 536 2432, 536 2433, 5303881, 530333, 530334, C12Q 168, G01N 3353, G01N 33543, C07H 2104

Patent

active

057766746

ABSTRACT:
An optical trap is used to translate a particle through a thin film coating on an optically-flat surface. Preferably, the thin film coating is heterogeneous and the optical trap is used to move the particle through a succession of different regions of the thin film coating where different chemical, biochemical and/or biological processes take place. Examples of chemical, biochemical and/or biological processes that might be implemented in accordance with the invention include the following: oligonucleotide synthesis and sequencing, peptide synthesis and sequencing, carbohydrate synthesis and sequencing, combinatorial library synthesis and screening, conventional (i.e., Sanger or Maxam-Gilbert) DNA sequengcing, or single-molecule DNA sequencing. In one embodiment of the invention, reaction products are left behind as the particle is moved through the thin film coating. Advantageously, these products can be identified by suitable means.

REFERENCES:
patent: 5079169 (1992-01-01), Chu et al.
Kuo and Sheetz, Science 260;232-234, 1995.

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