Chemical acetylation of desacetyl-cephalosporins

Details Chemical acetylation of desacetyl-cephalosporins Chemical acetylation of desacetyl-cephalosporins

1998-10-15

1999-06-29

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50104

Patent

active

059170328

ABSTRACT:
The present invention is concerned with a chemical acetylation process for the preparation of 3'-acetylated cephalosporin from desacetyl-cephalosporin. The novel process is carried out with an acetyl donor and an activator or catalyst.

REFERENCES:
patent: 3532694 (1970-10-01), Somerfield et al.
patent: 5221739 (1993-06-01), Wildfeuer
patent: 5512454 (1996-04-01), Usher
patent: 5552542 (1996-09-01), Reid et al.
G.G.F. Newton and E.P. Abraham, "Cephalosporin C, a New Antibiotic containing Sulphur and D-.alpha.-Aminoadipic Acid", Nature, 175, p. 548 (Mar. 26, 1955).

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