Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-25
2000-02-15
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514280, 600 1, A61N 4342, A61N 500
Patent
active
060253657
ABSTRACT:
Combination of low doses of irradiation and chelerythrine results in increased apoptosis in tumor cells. The doses of either irradiation or chelerythrine alone are such that increased apoptosis or decreased tumor growth or proliferation would not be expected.
REFERENCES:
patent: 209331 (1878-10-01), Daniel
patent: 433257 (1890-07-01), Ryan
patent: 2344830 (1944-03-01), Mohs
patent: 4145412 (1979-03-01), Ladanyi
patent: 4376115 (1983-03-01), McCrorey
patent: 4406881 (1983-09-01), Ladanyi
patent: 4599228 (1986-07-01), Ladanyi
patent: 5137912 (1992-08-01), Teng et al.
patent: 5324520 (1994-06-01), Dunn et al.
patent: 5571797 (1996-11-01), Ohno et al.
International Search Report dated Jul. 16, 1998 (PCT/US98/05842) (ARSB:517P).
Chmura et al., "Cross-talk between ceramide and PKC activity in the control of apoptosis," In: Mechanisms of Lymphocyte Activation and Immune Regulation VI, (eds Gupta, S. and Cohen, J.) Plenum Press, Adv. Experi. Medicine Biol., 406:39-55, 1996.
Slesak et al., "In vitro effects of Chelidonium majus L. alkaloid thiophosphoric acid conjugates (Ukrain) on the phenotype of normal human lymphocytes," Drugs Exptl. Clin. Res. XVIII (Suppl.) 17-21, 1992.
Kleinrok et al., Pol. J. Pharmacol. Pharm., 44:227-239, 1992.
Chmura et al., "Protein kinase C inhibition induces apoptosis and ceramide production through activation of a neutral sphingomyelinase," Cancer Research, 56:2711-2714, 1996.
Dewey et al., "Radiation-induced apoptosis: relevance to radiotherapy", Int. J. Radiation Oncology Biol. Phys., 33(4):781-796, 1995.
Haimovitz-Friedman et al., "Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis," J. Exp. Med., 180:525-35, 1994a.
Haimovitz-Friedman et al., Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis, Cancer Res., 54:2591-7, 1994b.
Herbert et al., "Chelerythrine is a potent and specific inhibitor of protein kinase C," Biochem. Biophys. Res. Commun., 172:993-999, 1990.
Jarvis et al., "Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells," The Journal of Biological Chemistry, 271(14):8275-8284, 1996.
Jarvis et al., "Ceramide and the induction of apoptosis," Clinical Cancer Research, 2:1-6, 1996.
Jarvis et al., "Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C" Cancer Research, 54:1707-1714, 1994.
Hallahan et al., "Inhibition of Protein Kinases Sensitizes Human Tumor Cells to Ionizing Radiation," Radiation Research, 129, pp. 345-350, 1992 publication month not available.
Watson et al., "Radiosensitization of HL-60 human leukemis cells by bryostatin-1 in the absence of increased DNA fragmentation or apoptotic cell death," Int. J. Radiat. Biol., 69(2):183-192, 1996.
Nakamura and Antoku, "Increase in postradiation survival of rat 3Y1 fibroblasts by a protein kinase inhibitor, staurosporine," Cancer Biochem. Biophys., 14:15-21, 1994.
Findik et al., "Protein Kinase A Inhibitors Enchance Radiation-Induced Apoptosis," Jouranl of Cellular Biochemistry, 57:12-21, 1995.
Grant et al., "Modulation of 1-[.beta.-D-Arabinofuranosyl] Cytosine-Induced Apoptosis in Human Myeloid Leukemia Cells by Staurosporine and Other Pharmacological Inhibitors of Protein Kinase C," Oncology Research, 6(2):87-99, 1994.
Kolesnick et al., "The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation," Biochem. Cell Biol., 72:471-474, 1994.
Krongrad and Bai, "c-fos promoter insensitivity to phorbol ester and possible role of protein kinase C in androgen-independent cancer cells" Cancer Research, 54:6073-6077, 1994.
Ma et al., "Phosphorylation of the multidrug resistance associated protein gene encoded protein P190," Biochemistry, 34:3338-3343, 1995.
Maity et al., "The molecular basis for cell cycle delays following ionizing radiation: a review," Radiother. Oncol., 31:1-13, 1994.
Quintans et al., "Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation," Biochem. Biophys. Res. Commun., 202:710-4, 1994.
Rosenthal et al., "Phase I studies of continuous-infusion paclitaxel given with standard aggressive radiation therapy for locally advanced solid tumors," Semin. Oncol., 22:13-17, 1995.
Sponsel et al., "Adenine nucleotide and protein kinase C regulation of renal tubular epithelial cell wound healing," Kidney Int., 48:85-92, 1995.
Verheij et al., "Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis," Nature, 380:75-79, 1996.
Vokes and Weichselbaum, "Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors," Journal of Clinical Oncology, 8(5):911-934, 1990.
Chmura Steven
Kufe Donald W.
Quintans Jose
Weichselbaum Ralph
Arch Development Corp.
Dana-Farber Cancer Institute
Dees Jos,e G.
Hartley Michael G.
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