Chelator compositions comprising oxime compounds

Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514461, 514473, 549473, A61K 742, A61K 3134, C07D31500

Patent

active

053646177

ABSTRACT:
The present invention involves photoprotective compositions which are useful for topical application to prevent damage to skin caused by acute or chronic exposure to ultraviolet light comprising chelating agents having the formula ##STR1## wherein --R.sup.1 and --R.sup.2 are independently selected from the group consisting of alkyl, aryl, and heteroaryl, or R.sup.1 and R.sup.2 may be covalently bonded together to form a cyclic alkyl; --M is selected from the group consisting of =0, =S, --SR.sup.4 and --OR.sup.4 (when --M is --OR.sup.4 or --SR.sup.4, there is a hydrogen bonded to the carbon to which --M is bonded); --R.sup.4 is selected from the group consisting of hydrogen, alkyl, aryl and heteroaryl; --R.sup.3 is selected from the group consisting of hydrogen, alkyl, aryl and heteroaryl; --R.sup.6 is selected from the group consisting of hydrogen alkyl, aryl and heteroaryl; and i is selected from the group consisting of one and zero. Methods for using such compositions to prevent damage to skin caused by acute or chronic exposure to ultraviolet light are al so involved.

REFERENCES:
patent: 3058886 (1962-10-01), Kreps
patent: 4240981 (1980-12-01), Kok
Fisher, W., E. Schilling, R. Schmiedel & M. Muller, "Antikonvulsive Wirkungen von Indolindervaten," Pharmazie, vol. 37, H. 12 (1982), pp. 858-861 (translation attached).
Gianturco, M. A., A. S. Giammarino, P. Friedel & V. Flanagan, "The Volatine Constituents of Coffee-IV Furanic and Pyrrolic Compounds", Tetrahedron, vol. 20 (1964), pp. 2951-2961.
Mulieri, L. A., G. Hasenfuss, F. Ittleman, E. M. Blanchard & N. R. Alpert, "Protection of Human Left Ventricular Myocardium From Cutting Injury With 2,3-Butanedione Monoxime", Circulation Research, vol. 65, No. 5 (1989), pp. 1441-1444.
Toul, J., "Thin-Layer and Paper Chromatography of Some 1,2-Dioximes and Their Monoximes", Journal of Chromatrography, vol. 57 (1971), pp. 107-119.
Owczarczyk, H., G. Borowska & D. Gajewski, "Pharmacological Investigations on New Monooximes as Acetylcholinesterase Reactivators", Pestycydy (Warsaw), vol. 3, No. 4 (1987), pp. 93-98 (translation attached).
Usui, T., "Studies on Furan Derivatives XI. Test for Antitumor Activity of Nitrofuran Derivatives", Journal of the Pharmaceutical Society of Japan, vol. 101, No. 1 (1981), pp. 90-93 (translation attached).
Chem. Abs 94:167640 Antitumor Activity of Nitrofuran 1981.
Chem Abs 88:190490 Furyl nitrofurans, 1978.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chelator compositions comprising oxime compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chelator compositions comprising oxime compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chelator compositions comprising oxime compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1095581

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.