Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-08-02
1995-10-31
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514249, 514252, 514266, 514269, 514308, 514364, 514378, 514381, 514397, 514406, 514438, 514444, 514471, 514640, 544237, 544238, 544264, 544296, 544353, 544357, 546140, 548125, 548247, 548252, 5483144, 5483654, 548518, 549 59, 549 60, 549472, 549492, 564253, 564256, 564265, A61K 3134, A61K 3138, A61K 3140, A61K 3115
Patent
active
054629632
ABSTRACT:
The present invention involves photoprotective compositions which are useful for topical application to prevent damage to skin caused by acute or chronic exposure to ultraviolet light comprising chelating agents having the structure: ##STR1## wherein each --R.sup.1 is independently selected from the group consisting of alkyl, aryl, heteroaryl and heterocycle, or the --R.sup.1 's are covalently bonded together to form a cyclic alkyl or heterocyclic ring; --R.sup.2 and --R.sup.3 are --OR.sup.4, in which case there is no bond or a polar bond between --R.sup.2 and the nitrogen covalently bonded to --R.sup.3, each --R.sup.4 being independently selected from the group consisting of hydrogen, alkyl and aryl, except that both --R.sup.4 's are not methyl when both --R.sup.1 's are furyl; or --R.sup.2 is --O-- and is covalently bonded to the nitrogen which is covalently bonded to --R.sup.3, and --R.sup.3 is --O-- (there being a + charge on the nitrogen to which it is bonded) or nil;
wherein the .alpha.-diamine compounds consist essentially of compounds wherein .dbd.NR.sup.2 and .dbd.NR.sup.3 are in amphi configuration when both --R.sup.2 and --R.sup.3 are --OH, and when both --R.sup.1 's are furyl or the --R.sup.1 's are covalently bonded together to form a cyclohexanedione structure.
Methods for using such compositions to prevent damage to skin caused by acute or chronic exposure to ultraviolet light are also involved.
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Bissett Donald L.
Bush Rodney D.
Graff Milton B.
Howell John M.
Raymond Richard L.
The Procter & Gamble & Company
Yetter Jerry J.
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