Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1996-03-12
1999-11-09
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
530331, 424 111, 424 165, 424 173, 534 14, A61K 5100, A61M 3614
Patent
active
059808616
ABSTRACT:
Compositions of radiolabeled nucleic acids and methods for synthesis and use thereof are disclosed.
REFERENCES:
patent: 4861869 (1989-08-01), Nicolotti et al.
patent: 5082930 (1992-01-01), Nicolotti et al.
patent: 5091514 (1992-02-01), Fritzberg et al.
patent: 5144043 (1992-09-01), Dean et al.
patent: 5218128 (1993-06-01), Dean et al.
patent: 5534497 (1996-07-01), Verbruggen
patent: 5541287 (1996-07-01), Yau et al.
patent: 5556982 (1996-09-01), Fritzberg et al.
patent: 5573748 (1996-11-01), Fritzberg
patent: 5605672 (1997-02-01), Bogdanov et al.
patent: 5616692 (1997-04-01), Fritzberg et al.
Fritzberg, A.R., "Advances in .sup.99m Tc-Labeling of Antibodies," Nucl.-Med., vol. 26, 7-12, (1987).
Fritzberg, A. R. et al., "Approaches to Radiolabeling of Antibodies for Diagnosis and Therapy of Cancer," Pharmaceutical Research, vol. 5, No. 6, 325-334 (1988).
Fritzberg, A. R. et al., "Synthesis and Biological Evaluation of Tc-99m N,N'-Bis(mercaptoacetyl)-2,3-diaminopropanoate: A Potential Replacement for [.sup.131 .vertline.]o-iodohippurate," The Journal of Nuclear Medicine, vol. 23, No. 7, 592-598 (1982).
Ram, S. and Buchsbaum, D., "A Peptide-Based Bifunctional Chelating Agent for .sup.99m Tc-and .sup.186 Re-Labeling of Monoclonal Antibodies," Cancer Supplement, vol. 73, No. 3, 769-773 (Feb. 1, 1994).
Abrams, Michael J. et al. (1990) "Technetium-99m-Human Ployclonal IgG Radiolabeled via the Hydrazino Nicotinamide Derivative for Imaging Focal Sites of Infection in Rats" The Journal of Nuclear Medicine 31(12):2022-2028.
Bos, Ebo S. et al. (1994) "In Vitro Evaluation of DNA-DNA Hybridization as a Two-Step Approach in Radioimmunotherapy of Cancer" Cancer Research 54:3479-3486.
Cazenave, Christian et al. (1987) "Rate of degradation of [.alpha.]-and [.beta.]-oligodeoxynucleotides in Xenopus oocytes. Implications for anti-messenger strategies" Nucleic Acids Research 15(24):10506-10521.
Dewanjee, Mrinal K. (1993) "Radiolabeled Antisense Probes: Diagnosis and Therapy" Diagn Oncol 3:189-208.
Dewanjee, Mrinal K. et al. (1994) "Noninvasive Imaging of c-myc Oncogene Messenger RNA with Indium-111-Antisense Probes in a Mammary Tumor-Bearing Mouse Model" J. Nucl Med 35:1054-1063.
Dewanjee, Mrinal K. et al. (1994) "Labeling Antisense Deoxyologonucleotide with Tc-99m and Hybridization with c-myc Oncogene MRNA in P388 Leukemic Cells" J. of Labelled Compounds and Radiopharmaceuticals 35:40-42.
Ducan, R. Julian S. et al. (1983) "A New Reagent Which May Be Used to Introduce Sulfhydryl Groups into Proteins, and Its Use in the Preparation of Conjugates for Immunoassey" Analytical Biochemistry 132:68-73.
Egholm, Michael et al. (1992) "Peptide Nucleic Acids (PNA). Oligonucleotide Analogues with an Achiral Peptide Backbone" J. Am. Chem Soc. 114:1895-1897.
Egholm, Micheal et al. (1993) "PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogenbonding rules" Nature 365:566-568.
Eisenhut, M. et al. (1996) "Bifunctional NHS-BAT Ester for Antibody Conjugation and Stable Technetium-99m Labeling: Conjugation Chemistry, Immunoreactivity and Kit Formation" J. of Nuclear Medicine 37:362-370.
Fritzberg, Alan R. (1986) "Synthesis and Biological Evaluation of Technetium-99m MAG.sub.3 as a Hippuran Replacement" J Nucl Med 27:111-116.
Goldrosen, M. H. (1990) "Biodistribution, Pharmocokinetic, and Imaging Studies with .sup.186 Relabeled NR-LU-10 Whole Antibody in LS174T Colonic Tumor-bearing Mice" Cancer Research 50:7973-7978.
Gordon, Eric M. et al. (1994) "Application of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions" J. of Medicinal Chemistry 37(10):1385-1401.
Hnatowich, D.J. et al. (1996) "Comparative Properties of a Technetium-99m-Labeled Single-Stranded Natural DNA and a Phosphorothioate Derivative in Vitro and in Mice" J. of Pharmacology and Experimental Therapeutics 276(1):326-334.
Hnatowich, D.J. et al. (1993) "Directly and Indirectly Technetium-99m-Labeled Antibodies--A Comparison of In Vitro and Animal In Vivo Properties" J. Nucl Med 34:109-119.
Hnatowich, D.J. et al. (1994) "Can a Cysteine Challenge Assay Predict the In Vivo Behavior of .sup.99m Tc-labeled antibodies?" Nucl. Med. Biol. 21(8):1035-1044.
Hnatowich, D.J. et al. (1995) "Technetium-99m Labeling of DNA Oligonucleotides" J. of Nuclear Medicine 36(12):2306-2314.
Wickstrom, Eric (1986) "Oligodeoxynucleotide Stability in Subcellular Extracts and Culture Media" J. of Biochemical and Biophysical Methods 13:97-102.
Winnard, P. Jr. and Hnatowich, D.J. (1995) "A method for the Facile Preparation of MAG3 Conjugated DNA-Used as an Alternative.sup.99m TC Labeling Method to Avoid Nonspecific Protein Binding" Eleventh International Symposium on Radiopharmaceutical Chemistry, Vancouver, B.C. Canada (Aug. 13-17, 1995).
Chang Fengchun
Hnatowich Donald J.
Mardirossian George
Rusckowski Mary
Winnard, Jr. Paul
Dees Jos,e G.
Jones Dameron
University of Massachusetts
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