Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-05-26
1993-04-20
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530408, 530409, 530410, 424 11, 424 9, C07K 1702, A61K 4902
Patent
active
052044483
ABSTRACT:
A new series of bifunctional chelating agents useful for attaching metal ions to proteins, polypeptides and other polymers and methods for their preparation are described. These reagents are unique in their ability to bind a variety of metal ions and to yield a high metal ion concentration per protein molecule. Using these methods polymeric analogs of these bifunctional chelating agents called Starburst ligands can also be obtained. Protein metal chelates thus obtained will have useful radiophysical, chemical, fluorescent, photochemical and magnetic properties suitable for biomedical applications.
REFERENCES:
Brechbiel et al (1986) Inorg. Chem. 25:2772-81.
Subramanian et al entitled "New Chelative Agent for Attaching Indium-III to monoclonal antibodies: In vitro and In vivo evaluation".
Akzo N.V.
Blackstone William M.
Kim Kay
Russel Jeffrey E.
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