Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-04-08
1994-03-08
Kim, Kay K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303911, 5303913, 5303917, 5303919, 530404, 530405, 530408, 530409, 436504, 436545, 436548, C07K 1528, C07K 1702, A61K 4902, A61K 3944
Patent
active
052928683
ABSTRACT:
A new series of bifunctional chelating agents useful for attaching metal ions to proteins, polypeptides and other polymers and methods for their preparation are described. These reagents are unique in their ability to bind a variety of metal ions and to yield a high metal ion concentration per protein molecule. Using these methods polymeric analogs of these bifunctional chelating agents called Starburst ligands can also be obtained. Protein metal chelates thus obtained will have useful radiophysical, chemical, fluorescent, photochemical and magnetic properties suitable for biomedical applications.
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Subramanian et al., "New Chelating Agent for Attaching Indium-111 to Monoclonal Antibodies: In Vitro and In Vivo Evalution", Bioconjugate Chemistry, (3) 1992.
Akzo N.V.
Blackstone William M.
Kim Kay K.
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