Chelated somatostatin peptides and complexes thereof, pharmaceut

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 16, 530311, 530317, 530328, 530304, 530324, A61K 3804, A61K 3831, C07K 708, C07K 14655

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active

057768943

ABSTRACT:
Somatostatin peptides bearing at least one chelating group for a detectable element, said chelating group being linked to an amino group of said peptide, and said amino group having no significant binding affinity for somatostatin receptors, in free or salt form, are complexed with a detectable element and are useful as a pharmaceutical, e.g. a radiopharmaceutical for in vivo imaging of somatostatin receptor positive tumors or for therapy.

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Journal of Clinical Endocrinology & Metabolism vol. 68, No. 2, pp. 239-246--Sassolas, et al. (1989).
Proc. Natl. Acad. Sci. USA vol. 83, pp. 1896-1900, Mar. 1996 Cai, et al.

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