Chelate derivatives of atrial natriuretic factor (ANF)

Details Chelate derivatives of atrial natriuretic factor (ANF) Chelate derivatives of atrial natriuretic factor (ANF)

1992-02-27

1993-09-28

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530408, 530409, C07K 710

Patent

active

052487644

ABSTRACT:
Derivatives of synthetic fragments of mammalian atrial natriuretic factor (ANF) in which a chelate molecule is attached to the N-terminal of the peptide are described. The chelate component allows the facile labelling of these peptides with metallic isotopes such as Tc-99m, Ga-67, In-111 and others. These radioactive chelates are useful in determining the in vivo behavior and fate of derivatives of ANF.

REFERENCES:
patent: 4352751 (1982-10-01), Wieder et al.

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