Chartreusin derivatives and salts thereof

Details Chartreusin derivatives and salts thereof Chartreusin derivatives and salts thereof

1986-10-23

1990-05-22

Lilling, Herbert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 172, 536 173, 536 175, 536 176, 536 179, 536 181, C07H 1704

Patent

active

049279190

ABSTRACT:
This invention relates to a novel chartreusin derivative of the general formula (I): ##STR1## and a salt thereof. This chartreusin derivative and a salt thereof have an excellent antitumor activity, which is exhibited even when the site of cancer inoculation and the site of drug administration are different. This invention further relates to a antitumorous composition containing the above-mentioned compound as active ingredient. This invention furthermore relates to a process for producing the above-mentioned chartreusin derivative or salt thereof.

REFERENCES:
patent: 4518589 (1985-05-01), Konishi et al.
patent: 4760136 (1988-07-01), Mori et al.
Ogawa, Y. et al., "The Absolute Structures of Rubeomycins A and A.sub.1 (Carminomycins II and III) and Rubeomycins B and B.sub.1 (4-Hydroxybaumycinols A.sub.1 and A.sub.2)", The Journal of Antibiotics, vol. XXXVII (1), Jan. 1984, pp. 44-56.
Ogawa, Y. et al., "Rubeomycin, A New Anthracycline Antibiotic Complex--I. Taxonomy of Producing Organism, Isolation, Characterization and Biological Activities of Rubeomycin A, A.sub.1, and B and B.sub.1 ", The Journal of Antibiotics, vol. XXXIV (8), Aug. 1981, pp. 938-950.
J. Am. Chem. Soc., 75, 4011-4012 (1953).
Cancer Research, 37, 1666-1672 (1977).
J. Med. Chem., 23, 549-553 (1980).
EPO Search Report dated Oct. 8, 1987.
Morrison et al., Organic Chemistry, 3rd ed., 1979, p. 673.

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