Chartreusin derivatives and salts thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 172, 536 181, C07H 1704

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active

050649450

ABSTRACT:
This invention relates to a novel chartreusin derivative of the general formula (I): ##STR1## and a salt thereof. This chartreusin derivative and a salt thereof have an excellent antitumor activity, which is exhibited even when the site of cancer inoculation and the site of drug administration are different. This invention further relates to an antitumorous composition containing the above-mentioned compound as active ingredient. This invention furthermore relates to a process for producing the above-mentioned chartreusin derivative or salt thereof.

REFERENCES:
patent: 4760136 (1988-07-01), Mori et al.
Ogawa, Y. et al. "The Absolute Structures of Rubeomycins A and A.sub.1, (Carminomycins II and III) and Rubeomycins B and B.sub.1 (4-Hydroxybaumycinols A.sub.1 and A.sub.2)", The Journal of Antibiotics; vol. 37, (1), Jan. 1984, pp. 44-56.
Ogawa, Y. et al., "Rubeomycin, A New Anthracycline Antibiotic Complex--I. Taxonomy of Producing Organism, Isolation, Characterization and Biological Activities of Rubeomycin A, A.sub.1, and B and B.sub.1." The Journal of Antibiotics, vol. 34 (8), Aug. 1981, pp. 938-950.

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