Charged collagen particle-based delivery matrix

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514801, 530356, 424422, 424423, 424484, 424491, A61K 3800, A61K 3817, A61F 1300

Patent

active

056772840

ABSTRACT:
A collagen-based delivery matrix including collagen particles, wherein each of the particles has a diameter between 5 .mu.m and 850 .mu.m and, when suspended in an aqueous solution at a pH of about 7.0, has a net charge density between -20 moles/mole collagen and -500 moles/mole collagen, or between +20 moles/mole collagen and +250 moles/mole collagen. Also disclosed are methods of preparing and using such a delivery matrix.

REFERENCES:
patent: 4394370 (1983-07-01), Jefferies
patent: 4472840 (1984-09-01), Jefferies
patent: 4539716 (1985-09-01), Bell
patent: 4657548 (1987-04-01), Nichols
patent: 4711783 (1987-12-01), Huc et al.
patent: 4774091 (1988-09-01), Yamahira et al.
patent: 4789662 (1988-12-01), Thomas-Leurquin et al.
patent: 4846835 (1989-07-01), Grande
patent: 4863732 (1989-09-01), Nathan et al.
patent: 5196185 (1993-03-01), Silver et al.
patent: 5206028 (1993-04-01), Li
patent: 5460962 (1995-10-01), Kemp
patent: 5532217 (1996-07-01), Silver et al.
Green et al, Biochemistry Journal, vol. 54, pp. 181-187, 1953.
Gustavson, Arkiv For Kemi, vol. 17, No. 55, pp. 541-550, Feb. 8, 1961.
Bradley et al., "Some Mechanical Property Considerations of Reconstituted Collagen For Drug Release Supports" Biomat., Med. Dev., Art. Org., 5(2), 159-175 (1977).
Cook et al, "In Vivo Evaluation of Recombinant Human Osteogenic Protein (rhOP-1) Implants As a Bone Graft Substitute for Spinal Fusions", Spine 19:1655-1663, 1994.
Fraenkel-Conrat et al., "Esterification of Protein With Alcohols of Low Molecular Weight", Journal B. C. 16:259-268, 1945.
Green et al., "Acetylation of Collagen", Biochemistry Journal, 54:181-187, 1953.
Gustavson et al., "Some Reactions of Succinylated Collagen", Arkiv Kemi 11:541-550, 1961.
Murray et al., "Collagen Shield Heparin Delivery for Prevention of Postoperative Fibrin", Arch Ophthalmol 108:104-106, 1990.
Nakano et al., "The Effect of Charges on Permeabilities of Drugs through Collagen Membranes", Chem. Pharm. Bull. 24(10)2345-2349, 1976.
Schwartz et al., "Collagen Shield Delivery of Amphotericin B", American Journal of Ophthalmology 109:701-704, 1990.
Weiner et al., "Liposome-Collagen Gel Matrix: A Novel Sustained Drug Delivery System", Journal of Pharm. Sciences 74:922-925, 1985.
Yasko et al., "The Healing of Segmental Bone Defects, Induced by Recombinant Human Bone Morphogenetic Protein (rhBMP-2)", The Journal of Bone and Joint Surgery 74-A, No. 5, 659-670, 1992.

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