Charge reversal of polyion complexes

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S455000

Reexamination Certificate

active

09328975

ABSTRACT:
An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.

REFERENCES:
patent: 4049595 (1977-09-01), Dominguez
patent: 5545423 (1996-08-01), Soon-Shiong et al.
patent: 5547932 (1996-08-01), Curiel et al.
patent: 5656611 (1997-08-01), Kabanov et al.
patent: 5908777 (1999-06-01), Lee et al.
patent: 6339067 (2002-01-01), Wolff et al.
patent: 6740336 (2004-05-01), Trubetskoy et al.
patent: 6740643 (2004-05-01), Wolff et al.
patent: 6818626 (2004-11-01), Wolff et al.
patent: 6881576 (2005-04-01), Wolff et al.
patent: WO 97/00965 (1997-01-01), None
Verma et al. Nature 389: 239-242 , especially p. 239, Sep. 1997.
Orkin (Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, see p. 1, item 3, and p. 9, Dec. 1995.
Anderson et al. Nature 392: 25-30, especially pp. 25 and 30, Apr. 1998.
Nicolau et al (Biochim. Biophys. Acta 721(2): 185-190, See abstract; p. 187, col. 2, lines 3 and 4 of first full paragraph; and Table 1, p. 188, section A of Table 1, Oct. 1982.
Vitiello et al Gene Therapy 3(5): 396-404, see abstract, May 1996.
Baker et al (Nucl. Acids Res. 25(10): 1950-1956, see last sentence of abstract, May 1997.
Boussif et. al.; A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine, 1995, Proc. Natl. Acad. Sci. vol. 92: 7297-7301.
Joel M. Kupfer et al., Human Gene Therapy, 5: pp. 1437-1443 (Dec. 1994).
L. Gao et al., Human Gene Therapy, 4; pp. 17-24 (1993).
Patrick Erbacher et al., Drug Delivery, 4: pp. 173-179 (1997).
Christian Plank et al., The Journal of Biological Chemistry, vol. 269, No. 17, Apr. 29, 1994, pp. 12918-12924.
Satoshi Katayose et al., Bioconjugate Chem. 1997, 8, pp. 702-707.
Richards et al (J. Chromatog. (1997) 690(1-2): 43-54).
GenBank Accession No. AAB22049 (May 7, 1993).
1998 Promega Catalog, p. 245.
1995 New England BioLabs Catalog, p. 186.
Christens-Barry et al (Biopolymers (1989) 28(9): 1515-1526).
Baker et al (Gene Therapy 4:773-782, Jul. 31, 1997).
Degols et al (Nucl. Acids Res. 19(4): 945-948, 1991).
Leonetti et al (J. Nat. Cancer Inst. 88(7): 419-429, 1996).
Wiethoff et al (J. Biol. Chem. 276(35): 32806-32813, 2001).
Wu et al (J. Biol. Chem. 269(29): 14621-14624, 1988).
Livnah O et al. “Three-dimensional structures of avidin and the avidin-biotin complex,” Proc. Natl. Acad. Sci. USA; 1993 vol. 90 pp. 5076-5080.
Weber PC et al. “Structural origins of high-affinity biotin binding to streptavidin,” Science; 1989 vol. 243 pp. 85-88.
Pugliese L et al. “Three-dimensional structure of the tetragonal crystal form of egg-white avidin in its function complex with biotin at 2.7 A resolution,” J Molecular Biol; 1993 vol. 231, No. 3, pp. 698-710.
Bloomfield, V., “DNA Condensation.”Current Opinion in Structural Biology1996; 6; 334-341.
Dash, P. Et al., “Factors Affecting Blood Clearance and In Vivo Distribution of Polyelectrolyte Complexes for Gene Delivery.”Gene Therapy1999; 6; 643-650.
Dash, P. Et Al., “Synthetic Polymers For Vectorial Delivery of DNA: Characterisation of Polymer-DNA Complexes by Photon Correlation Spectroscopy and Stability to Nuclease Degradation and Disruption by Polyanions in Vitro.”Journal of Controlled Release1997; 48; 269-276.
Haensler, J. Et al., “Polyamidoamine Cascade Polymers Mediate Efficient Transfection of Cells in Culture.”Bioconjugate Chemistry1993; 4; 372-379.
Hansma, H. Et al., “DNA Condensation for Gene Therapy as Monitored By Atomic Force Microscopy.”Nucleic Acids Research1998; vol. 26, No. 10; 2481-2487.
Kabanov, A. Et al., “Interpolyelectrolyte and Block Ionomer Complexes for Gene Delivery: Physico-chemical Aspects.”Advanced Drug Delivery Reviews1998; 30; 49-60.
Kichler, A. Et al., “Influence of Membrane-Active Peptides on Lipospermine/DNA Complex Mediated Gene Transfer.”Bioconjugate Chem.1997; 8; 213-221.
Maruyama, A. Et et al., “Nanopartical DNA Carrier with Poly)L-lysine) Grafted Polysaccharide Copolymer and Poly(D,L-lactic acid).”Bioconjugate Chemistry(1997) 8; 735-42.
Ogris, M. Et al., “PEGylated DNA/Transferrin-PEI Complexes: Reduced Interaction with Blood Components, Extended Circulation in Blood and Potential for Systemic Gene Delivery.”Gene Therapy1999; 6; 595-605.
Plank, C. Et al., “The Influence of Endosome-disruptive Peptides on Gene Transfer Using Synthetic Virus-like Gene Transfer Systems.”The Journal of Biological ChemistryApr. 29, 1994; vol. 269, No. 17; 12918-12924.
Talingting, M.R. Et al., “Cationic Copolymer Micelles and Anionic Polyelectrolytes Forming Onion-Type Micelles.”Polymer Preprints1999; vol. 40, No. 2; 240-241.
Tang, MX, Et al., “The Influence of Polymer Structure on the Interactions of Cationic Polymers with DNA and Morphology of the Resulting Complexes.”Gene Therapy1997; 4; 823-832.
Trubeskoy, V. Et al., “Layer-by-Layer Deposition of Oppositely Charged Polyelectrolytes on the Surface of Condensed DNA Particles.”Nucleic Acids Research1999; vol. 27, No. 15; 3090-3095.
Trubetskoy, V. Et al., “Quantitative Assessment of DNA Condensation.”Analytical Biochemistry1999; 267; 309-313.
Wolfert, M. Et al., “Characterization of Vectors for Gene Formed by Self-Assembly of DNA with Synthetic Block Co-Polymers.”Human Gene TherapyNov. 10, 1996; 7; 2123-2133.
Xu, Y. Et al., “Mechanism of DNA Release From Cationic Liposome/DNA Complexes Used in Cell Transfection.”Biochemistry1996; 35; 5616-5623.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Charge reversal of polyion complexes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Charge reversal of polyion complexes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Charge reversal of polyion complexes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3905974

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.