Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Reexamination Certificate
2005-10-04
2008-09-02
Jones, D. L. (Department: 1618)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
C424S001110, C424S001650, C424S009100, C424S009300, C424S009360
Reexamination Certificate
active
07419654
ABSTRACT:
A contrast agent for magnetic resonance imaging comprising a complex of a paramagnetic cation, preferably Gd+3, Dy+3, and Fe+3with three equivalents of a charge neutralizing chelator that provides a lipid soluble complex of the paramagnetic cation is described. The complex is retained intracellularly when introduced into a mammalian cell. A method of providing an image of an internal pathology of a patient by magnetic resonance imaging (MRI) by administering the MRI contrast agent or tagged cells to the patient and scanning the patient using magnetic resonance imaging to obtain visible images of the internal pathology of the patient is also set forth.
REFERENCES:
patent: 2755280 (1956-07-01), Feigin et al.
patent: 4443426 (1984-04-01), Thakur
patent: 4615879 (1986-10-01), Runge et al.
patent: 5308606 (1994-05-01), Wilson et al.
patent: 5312617 (1994-05-01), Unger et al.
patent: 5401492 (1995-03-01), Kellar et al.
patent: 5466438 (1995-11-01), Unger et al.
patent: 5624662 (1997-04-01), Unger et al.
patent: 5762910 (1998-06-01), Unger et al.
patent: 6010682 (2000-01-01), Unger et al.
patent: 6146614 (2000-11-01), Rubin et al.
patent: 6242007 (2001-06-01), Mohseni et al.
patent: 6685913 (2004-02-01), Thakur
Ibrahim, S. et al., J. Inorg. Biochem., 1986, 28(1), p. 57-65.
Giacometti, A. et al., Am. J. Neuroradiology, 1993, 14, p. 123-127 (abstract).
Dewanjee et al., Investigative Radiology, vol. 19, No. 6, pp. 535-539 and 542, Nov.-Dec. 1984.
Dewanjee et al., Circulation, vol. 69, pp. 350-356 (1984).
Dietrich et al., “Platelet Accumulation After Carotid Thrombosis”, Stroke, vol. 24, No. 10, pp. 1534-1540, Oct. 1993.
Holman et al., jnm/Concise Communication, vol. 14, No. 8, pp. 595-599, Jan. 9, 1973.
Dewanjee, “Assessment of Thrombosis in Vivo”, Annals of the New York Academy of Sciences, vol. 516, pp. 541-571 (1987).
Dewanjee Mrinal K.
Jones D. L.
LandOfFree
Charge neutral complexes of paramagnetic metals as... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Charge neutral complexes of paramagnetic metals as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Charge neutral complexes of paramagnetic metals as... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3975871