Charge effects in enzyme immunoassays

Details Charge effects in enzyme immunoassays Charge effects in enzyme immunoassays

1982-05-01

1985-02-26

Kight, John

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 424 85, 424101, 436547, A61K 3514, A61K 3700, A61K 3900

Patent

active

045016925

ABSTRACT:
A method for determining a member of a specific binding pair-ligand and receptor (antiligand). Reagents employed include a first modified member which provides an electrical field due to the presence of a plurality of ionic charges and a second modified member labeled with a component of a signal producing system, which system may have one or more components. The average proximity in the assay medium of the first and second modified members is related to the amount of analyte, where the observed signal from the signal producing system is related to the effect of the electrical field on the signal producing system.
Also, compositions are provided, as well as reagents, in predetermined ratios for optimizing the signal response to variations in analyte concentration.

REFERENCES:
patent: 4017471 (1977-04-01), Davies
patent: 4259233 (1981-03-01), Carrico et al.
patent: 4315851 (1982-02-01), Yoshikumi
patent: 4356173 (1982-10-01), Miura et al.
Freedman et al., Biochemistry 7(5), 1968, pp. 1941-1950, The Effects of Complete Modification of Amine Groups . . . Anhydride.

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