Radiant energy – Luminophor irradiation – With ultraviolet source
Patent
1996-03-06
1997-09-30
Fields, Carolyn E.
Radiant energy
Luminophor irradiation
With ultraviolet source
2504581, G01N 2164
Patent
active
056728816
ABSTRACT:
An apparatus for fluorescence of a biological sample includes a light illumination source, an ambient light-excluding optical chamber, a sample holder, a two-dimensional array charge coupled device ("CCD") sensor providing for on-chip signal integration of each pixel of the array, and an analog/digital converter for digitizing the CCD signal. Signal acquisition time from the array is varied so that the integrated signal from each pixel is below its saturation level. A darkfield value for each pixel is acquired and subtracted from the illuminated signal from that pixel so as to yield a darkfield corrected signal. The fluorescence value for each pixel can be compensated for variations in excitation energy reaching different sample areas. Image readout is through a single channel output.
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Edridge Peter
Klock John C.
Starr Christopher M.
Striepeke Steven K.
Fields Carolyn E.
Glyko, Inc.
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