Characterizing macromolecules interacting with at least three li

Details Characterizing macromolecules interacting with at least three li Characterizing macromolecules interacting with at least three li

1994-12-30

1996-09-10

Housel, James C.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

422 8205, 422 8208, 422 8211, 436165, 436527, 436536, 436805, G01N 33543

Patent

active

055545416

ABSTRACT:
A method of characterizing a macromolecule by studying its interactions with ligands comprises the determination of the mutual influence of ligand interactions by, after the macromolecule has interacted with at least one ligand, contacting the macromolecule with at least one additional ligand, either the macromolecule or the additional ligand or ligands having been bound to a sensor surface, determining interaction by detecting a consequential change in the physico-chemical properties of the sensor surface, and on the basis of the determined mutual dependence between the ligand interactions discriminating between epitopes of the macromolecule and mapping their relative positions.

REFERENCES:
patent: 4659678 (1987-04-01), Forrest et al.
patent: 5104790 (1992-04-01), Flesher et al.
Chemical Abstracts, vol. 109, No. 19, Abstract No. 166540v (1988).
Katchalski-Katzir et al, Bull. Chem. Soc. Jpn., vol. 61, pp. 133-139 (1988).
Fagerstam et al, "Biospecific interaction analysis using surface plasmon resonance detection . . . ", Journal of Chromatography, 597 (1992), pp. 397-410.
Wagener et al, "Monoclonal Antibodies For Carcinoembryonic Antigen & Related Antigens as a Model system . . . ", Journal of Immunology, 130(5), May 1983, pp. 2308-2315.
Oi and Herzenberg, "Localization of Marine Ig-1b and Ig-1a (IgG.sub.2a) Allotypic Determinants Detected with Monoclonal Antibodies", Molecular Immunology, vol. 16, 1979, pp. 1005-1017.

Affiliated with

Also associated with

Rating

Characterizing macromolecules interacting with at least three li does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Characterizing macromolecules interacting with at least three li, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Characterizing macromolecules interacting with at least three li will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1320021